In vivo genome‐editing screen identifies tumor suppressor genes that cooperate with Trp53 loss during mammary tumorigenesis

Breast cancer is a heterogeneous disease that comprises multiple histological and molecular subtypes. To gain insight into mutations that drive breast tumorigenesis, we describe a pipeline for the identification and validation of tumor suppressor genes. Based on an in vivo genome‐wide CRISPR/Cas9 sc...

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Detalles Bibliográficos
Autores principales: Heitink, Luuk, Whittle, James R., Vaillant, François, Capaldo, Bianca D., Dekkers, Johanna F., Dawson, Caleb A., Milevskiy, Michael J. G., Surgenor, Elliot, Tsai, Minhsuang, Chen, Huei‐Rong, Christie, Michael, Chen, Yunshun, Smyth, Gordon K., Herold, Marco J., Strasser, Andreas, Lindeman, Geoffrey J., Visvader, Jane E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8895454/
https://www.ncbi.nlm.nih.gov/pubmed/35000262
http://dx.doi.org/10.1002/1878-0261.13179

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