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Circular RNA detection identifies circPSEN1 alterations in brain specific to autosomal dominant Alzheimer's disease

BACKGROUND: Autosomal-dominant Alzheimer's disease (ADAD) is caused by pathogenic mutations in APP, PSEN1, and PSEN2, which usually lead to an early age at onset (< 65). Circular RNAs are a family of non-coding RNAs highly expressed in the nervous system and especially in synapses. We aimed...

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Detalles Bibliográficos
Autores principales:	Chen, Hsiang-Han, Eteleeb, Abdallah, Wang, Ciyang, Fernandez, Maria Victoria, Budde, John P., Bergmann, Kristy, Norton, Joanne, Wang, Fengxian, Ebl, Curtis, Morris, John C., Perrin, Richard J., Bateman, Randall J., McDade, Eric, Xiong, Chengjie, Goate, Alison, Farlow, Martin, Chhatwal, Jasmeer, Schofield, Peter R., Chui, Helena, Harari, Oscar, Cruchaga, Carlos, Ibanez, Laura
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8895634/ https://www.ncbi.nlm.nih.gov/pubmed/35246267 http://dx.doi.org/10.1186/s40478-022-01328-5

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