GWAS meta-analysis followed by Mendelian randomization revealed potential control mechanisms for circulating α-Klotho levels

The protein α-Klotho acts as transmembrane co-receptor for fibroblast growth factor 23 (FGF23) and is a key regulator of phosphate homeostasis. However, α-Klotho also exists in a circulating form, with pleiotropic, but incompletely understood functions and regulation. Therefore, we undertook a genom...

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Detalles Bibliográficos
Autores principales: Gergei, Ingrid, Zheng, Jie, Andlauer, Till F M, Brandenburg, Vincent, Mirza-Schreiber, Nazanin, Müller-Myhsok, Bertram, Krämer, Bernhard K, Richard, Daniel, Falk, Louise, Movérare-Skrtic, Sofia, Ohlsson, Claes, Davey Smith, George, März, Winfried, Voelkl, Jakob, Tobias, Jonathan H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
General Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8895756/
https://www.ncbi.nlm.nih.gov/pubmed/34542150
http://dx.doi.org/10.1093/hmg/ddab263

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