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Multifunctional photodynamic/photothermal nano-agents for the treatment of oral leukoplakia

Oral leukoplakia (OLK) has gained extensive attention because of the potential risk for malignant transformation. Photosensitizers (PSs) played an indispensable role in the photodynamic therapy (PDT) of OLK, but the poor light sensitivity greatly hampered its clinical application. Herein, a novel or...

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Autores principales: Lin, Lin, Song, Chuanhui, Wei, Zheng, Zou, Huihui, Han, Shengwei, Cao, Zichen, Zhang, Xinyu, Zhang, Guorong, Ran, Jianchuan, Cai, Yu, Han, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8895861/
https://www.ncbi.nlm.nih.gov/pubmed/35246146
http://dx.doi.org/10.1186/s12951-022-01310-2
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author Lin, Lin
Song, Chuanhui
Wei, Zheng
Zou, Huihui
Han, Shengwei
Cao, Zichen
Zhang, Xinyu
Zhang, Guorong
Ran, Jianchuan
Cai, Yu
Han, Wei
author_facet Lin, Lin
Song, Chuanhui
Wei, Zheng
Zou, Huihui
Han, Shengwei
Cao, Zichen
Zhang, Xinyu
Zhang, Guorong
Ran, Jianchuan
Cai, Yu
Han, Wei
author_sort Lin, Lin
collection PubMed
description Oral leukoplakia (OLK) has gained extensive attention because of the potential risk for malignant transformation. Photosensitizers (PSs) played an indispensable role in the photodynamic therapy (PDT) of OLK, but the poor light sensitivity greatly hampered its clinical application. Herein, a novel organic photosensitive ITIC-Th nanoparticles (ITIC-Th NPs) were developed for OLK photodynamic/photothermal therapy (PTT). ITIC-Th NPs present both high photothermal conversion efficiency (~ 38%) and suitable reactive oxygen species (ROS) generation ability under 660 nm laser irradiation, making them possess excellent PDT and PTT capability. In 4-nitroquinoline 1-oxide (4NQO)-induced oral precancerous animal models, ITIC-Th NPs effectively suppress the OLK's cancerization without apparent topical or systemic toxicity in vivo. This study offers a promising therapeutic strategy for PDT and PTT in OLK treatment, and this study is the first interdisciplinary research in the field of multimodal therapy for OLK. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12951-022-01310-2.
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spelling pubmed-88958612022-03-10 Multifunctional photodynamic/photothermal nano-agents for the treatment of oral leukoplakia Lin, Lin Song, Chuanhui Wei, Zheng Zou, Huihui Han, Shengwei Cao, Zichen Zhang, Xinyu Zhang, Guorong Ran, Jianchuan Cai, Yu Han, Wei J Nanobiotechnology Research Oral leukoplakia (OLK) has gained extensive attention because of the potential risk for malignant transformation. Photosensitizers (PSs) played an indispensable role in the photodynamic therapy (PDT) of OLK, but the poor light sensitivity greatly hampered its clinical application. Herein, a novel organic photosensitive ITIC-Th nanoparticles (ITIC-Th NPs) were developed for OLK photodynamic/photothermal therapy (PTT). ITIC-Th NPs present both high photothermal conversion efficiency (~ 38%) and suitable reactive oxygen species (ROS) generation ability under 660 nm laser irradiation, making them possess excellent PDT and PTT capability. In 4-nitroquinoline 1-oxide (4NQO)-induced oral precancerous animal models, ITIC-Th NPs effectively suppress the OLK's cancerization without apparent topical or systemic toxicity in vivo. This study offers a promising therapeutic strategy for PDT and PTT in OLK treatment, and this study is the first interdisciplinary research in the field of multimodal therapy for OLK. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12951-022-01310-2. BioMed Central 2022-03-04 /pmc/articles/PMC8895861/ /pubmed/35246146 http://dx.doi.org/10.1186/s12951-022-01310-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Lin, Lin
Song, Chuanhui
Wei, Zheng
Zou, Huihui
Han, Shengwei
Cao, Zichen
Zhang, Xinyu
Zhang, Guorong
Ran, Jianchuan
Cai, Yu
Han, Wei
Multifunctional photodynamic/photothermal nano-agents for the treatment of oral leukoplakia
title Multifunctional photodynamic/photothermal nano-agents for the treatment of oral leukoplakia
title_full Multifunctional photodynamic/photothermal nano-agents for the treatment of oral leukoplakia
title_fullStr Multifunctional photodynamic/photothermal nano-agents for the treatment of oral leukoplakia
title_full_unstemmed Multifunctional photodynamic/photothermal nano-agents for the treatment of oral leukoplakia
title_short Multifunctional photodynamic/photothermal nano-agents for the treatment of oral leukoplakia
title_sort multifunctional photodynamic/photothermal nano-agents for the treatment of oral leukoplakia
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8895861/
https://www.ncbi.nlm.nih.gov/pubmed/35246146
http://dx.doi.org/10.1186/s12951-022-01310-2
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