Acute Cerebellitis Associated With Anti-homer 3 Antibodies: A Rare Case Report and Literature Review

Acute cerebellitis associated with Homer-3 antibodies is very rare. Here we present a 20-year-old woman who suffered from uncontrollable head shaking quickly from side to side and an unsteady gait for 2 days after the cold. Antibodies were screened by cell-based assays. The indirect immunofluorescen...

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Detalles Bibliográficos
Autores principales: Miao, Ailiang, Yu, Chuanyong, Sun, Yulei, Wang, Lingling, Ge, Jianqing, Wang, Xiaoshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8895947/
https://www.ncbi.nlm.nih.gov/pubmed/35250837
http://dx.doi.org/10.3389/fneur.2022.837937
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author Miao, Ailiang
Yu, Chuanyong
Sun, Yulei
Wang, Lingling
Ge, Jianqing
Wang, Xiaoshan
author_facet Miao, Ailiang
Yu, Chuanyong
Sun, Yulei
Wang, Lingling
Ge, Jianqing
Wang, Xiaoshan
author_sort Miao, Ailiang
collection PubMed
description Acute cerebellitis associated with Homer-3 antibodies is very rare. Here we present a 20-year-old woman who suffered from uncontrollable head shaking quickly from side to side and an unsteady gait for 2 days after the cold. Antibodies were screened by cell-based assays. The indirect immunofluorescence technique results revealed anti-Homer-3 antibody titers of 1:3.2 in the CSF and 1:100 in the serum. The woman was obviously improved after antiviral and immunosuppression (immunoglobin, methylprednisolone and mycophenolate mofetil) treatment. Our report indicated immune-mediated causes should be considered in the acute cerebellitis. Immunotherapy can contribute to the improvement of cerebellar syndrome.
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spelling pubmed-88959472022-03-05 Acute Cerebellitis Associated With Anti-homer 3 Antibodies: A Rare Case Report and Literature Review Miao, Ailiang Yu, Chuanyong Sun, Yulei Wang, Lingling Ge, Jianqing Wang, Xiaoshan Front Neurol Neurology Acute cerebellitis associated with Homer-3 antibodies is very rare. Here we present a 20-year-old woman who suffered from uncontrollable head shaking quickly from side to side and an unsteady gait for 2 days after the cold. Antibodies were screened by cell-based assays. The indirect immunofluorescence technique results revealed anti-Homer-3 antibody titers of 1:3.2 in the CSF and 1:100 in the serum. The woman was obviously improved after antiviral and immunosuppression (immunoglobin, methylprednisolone and mycophenolate mofetil) treatment. Our report indicated immune-mediated causes should be considered in the acute cerebellitis. Immunotherapy can contribute to the improvement of cerebellar syndrome. Frontiers Media S.A. 2022-02-18 /pmc/articles/PMC8895947/ /pubmed/35250837 http://dx.doi.org/10.3389/fneur.2022.837937 Text en Copyright © 2022 Miao, Yu, Sun, Wang, Ge and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Miao, Ailiang
Yu, Chuanyong
Sun, Yulei
Wang, Lingling
Ge, Jianqing
Wang, Xiaoshan
Acute Cerebellitis Associated With Anti-homer 3 Antibodies: A Rare Case Report and Literature Review
title Acute Cerebellitis Associated With Anti-homer 3 Antibodies: A Rare Case Report and Literature Review
title_full Acute Cerebellitis Associated With Anti-homer 3 Antibodies: A Rare Case Report and Literature Review
title_fullStr Acute Cerebellitis Associated With Anti-homer 3 Antibodies: A Rare Case Report and Literature Review
title_full_unstemmed Acute Cerebellitis Associated With Anti-homer 3 Antibodies: A Rare Case Report and Literature Review
title_short Acute Cerebellitis Associated With Anti-homer 3 Antibodies: A Rare Case Report and Literature Review
title_sort acute cerebellitis associated with anti-homer 3 antibodies: a rare case report and literature review
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8895947/
https://www.ncbi.nlm.nih.gov/pubmed/35250837
http://dx.doi.org/10.3389/fneur.2022.837937
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