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Ocular adnexal mucosa-associated lymphoid tissue lymphoma: a narrative review

Lymphoma is the most common primary tumor of the orbit, accounting for 55% of all orbital malignancies. When divided into histopathological subtypes, extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) comprises the largest proportion. Clinical manifestations are u...

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Detalles Bibliográficos
Autores principales: Chung, Hyun Uk, Son, Jun Hyuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Journal of Yeungnam Medical Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8895963/
https://www.ncbi.nlm.nih.gov/pubmed/34521183
http://dx.doi.org/10.12701/yujm.2021.01263
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author Chung, Hyun Uk
Son, Jun Hyuk
author_facet Chung, Hyun Uk
Son, Jun Hyuk
author_sort Chung, Hyun Uk
collection PubMed
description Lymphoma is the most common primary tumor of the orbit, accounting for 55% of all orbital malignancies. When divided into histopathological subtypes, extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) comprises the largest proportion. Clinical manifestations are unspecific, but in patients with slow-growing painless orbital mass, or red conjunctival lesion suggestive of ‘salmon patch’, ocular adnexa lymphoma (OAL) should be suspected. Although the pathogenetic mechanism of ocular adnexal MALT lymphoma (OAML) is not yet fully understood, the relationship between OAML and Chlamydia psittaci has been hypothesized recently, similar to that between gastric MALT lymphoma and Helicobacter pylori. This suggests a new treatment option for OAML; bacterial eradication therapy with systemic antibiotics. Several other treatment methods for OAML have been introduced, but no treatment guidelines have been established yet. In this article, we summarize the current knowledge on the clinical features, pathogenesis, diagnostic methods, therapeutic strategies, and prognosis of OAML.
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spelling pubmed-88959632022-03-04 Ocular adnexal mucosa-associated lymphoid tissue lymphoma: a narrative review Chung, Hyun Uk Son, Jun Hyuk J Yeungnam Med Sci Review Article Lymphoma is the most common primary tumor of the orbit, accounting for 55% of all orbital malignancies. When divided into histopathological subtypes, extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) comprises the largest proportion. Clinical manifestations are unspecific, but in patients with slow-growing painless orbital mass, or red conjunctival lesion suggestive of ‘salmon patch’, ocular adnexa lymphoma (OAL) should be suspected. Although the pathogenetic mechanism of ocular adnexal MALT lymphoma (OAML) is not yet fully understood, the relationship between OAML and Chlamydia psittaci has been hypothesized recently, similar to that between gastric MALT lymphoma and Helicobacter pylori. This suggests a new treatment option for OAML; bacterial eradication therapy with systemic antibiotics. Several other treatment methods for OAML have been introduced, but no treatment guidelines have been established yet. In this article, we summarize the current knowledge on the clinical features, pathogenesis, diagnostic methods, therapeutic strategies, and prognosis of OAML. Journal of Yeungnam Medical Science 2021-09-15 /pmc/articles/PMC8895963/ /pubmed/34521183 http://dx.doi.org/10.12701/yujm.2021.01263 Text en Copyright © 2022 Yeungnam University College of Medicine, Yeungnam University Institute of Medical Science https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Chung, Hyun Uk
Son, Jun Hyuk
Ocular adnexal mucosa-associated lymphoid tissue lymphoma: a narrative review
title Ocular adnexal mucosa-associated lymphoid tissue lymphoma: a narrative review
title_full Ocular adnexal mucosa-associated lymphoid tissue lymphoma: a narrative review
title_fullStr Ocular adnexal mucosa-associated lymphoid tissue lymphoma: a narrative review
title_full_unstemmed Ocular adnexal mucosa-associated lymphoid tissue lymphoma: a narrative review
title_short Ocular adnexal mucosa-associated lymphoid tissue lymphoma: a narrative review
title_sort ocular adnexal mucosa-associated lymphoid tissue lymphoma: a narrative review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8895963/
https://www.ncbi.nlm.nih.gov/pubmed/34521183
http://dx.doi.org/10.12701/yujm.2021.01263
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