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Ocular adnexal mucosa-associated lymphoid tissue lymphoma: a narrative review
Lymphoma is the most common primary tumor of the orbit, accounting for 55% of all orbital malignancies. When divided into histopathological subtypes, extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) comprises the largest proportion. Clinical manifestations are u...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Journal of Yeungnam Medical Science
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8895963/ https://www.ncbi.nlm.nih.gov/pubmed/34521183 http://dx.doi.org/10.12701/yujm.2021.01263 |
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author | Chung, Hyun Uk Son, Jun Hyuk |
author_facet | Chung, Hyun Uk Son, Jun Hyuk |
author_sort | Chung, Hyun Uk |
collection | PubMed |
description | Lymphoma is the most common primary tumor of the orbit, accounting for 55% of all orbital malignancies. When divided into histopathological subtypes, extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) comprises the largest proportion. Clinical manifestations are unspecific, but in patients with slow-growing painless orbital mass, or red conjunctival lesion suggestive of ‘salmon patch’, ocular adnexa lymphoma (OAL) should be suspected. Although the pathogenetic mechanism of ocular adnexal MALT lymphoma (OAML) is not yet fully understood, the relationship between OAML and Chlamydia psittaci has been hypothesized recently, similar to that between gastric MALT lymphoma and Helicobacter pylori. This suggests a new treatment option for OAML; bacterial eradication therapy with systemic antibiotics. Several other treatment methods for OAML have been introduced, but no treatment guidelines have been established yet. In this article, we summarize the current knowledge on the clinical features, pathogenesis, diagnostic methods, therapeutic strategies, and prognosis of OAML. |
format | Online Article Text |
id | pubmed-8895963 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Journal of Yeungnam Medical Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-88959632022-03-04 Ocular adnexal mucosa-associated lymphoid tissue lymphoma: a narrative review Chung, Hyun Uk Son, Jun Hyuk J Yeungnam Med Sci Review Article Lymphoma is the most common primary tumor of the orbit, accounting for 55% of all orbital malignancies. When divided into histopathological subtypes, extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) comprises the largest proportion. Clinical manifestations are unspecific, but in patients with slow-growing painless orbital mass, or red conjunctival lesion suggestive of ‘salmon patch’, ocular adnexa lymphoma (OAL) should be suspected. Although the pathogenetic mechanism of ocular adnexal MALT lymphoma (OAML) is not yet fully understood, the relationship between OAML and Chlamydia psittaci has been hypothesized recently, similar to that between gastric MALT lymphoma and Helicobacter pylori. This suggests a new treatment option for OAML; bacterial eradication therapy with systemic antibiotics. Several other treatment methods for OAML have been introduced, but no treatment guidelines have been established yet. In this article, we summarize the current knowledge on the clinical features, pathogenesis, diagnostic methods, therapeutic strategies, and prognosis of OAML. Journal of Yeungnam Medical Science 2021-09-15 /pmc/articles/PMC8895963/ /pubmed/34521183 http://dx.doi.org/10.12701/yujm.2021.01263 Text en Copyright © 2022 Yeungnam University College of Medicine, Yeungnam University Institute of Medical Science https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Chung, Hyun Uk Son, Jun Hyuk Ocular adnexal mucosa-associated lymphoid tissue lymphoma: a narrative review |
title | Ocular adnexal mucosa-associated lymphoid tissue lymphoma: a narrative review |
title_full | Ocular adnexal mucosa-associated lymphoid tissue lymphoma: a narrative review |
title_fullStr | Ocular adnexal mucosa-associated lymphoid tissue lymphoma: a narrative review |
title_full_unstemmed | Ocular adnexal mucosa-associated lymphoid tissue lymphoma: a narrative review |
title_short | Ocular adnexal mucosa-associated lymphoid tissue lymphoma: a narrative review |
title_sort | ocular adnexal mucosa-associated lymphoid tissue lymphoma: a narrative review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8895963/ https://www.ncbi.nlm.nih.gov/pubmed/34521183 http://dx.doi.org/10.12701/yujm.2021.01263 |
work_keys_str_mv | AT chunghyunuk ocularadnexalmucosaassociatedlymphoidtissuelymphomaanarrativereview AT sonjunhyuk ocularadnexalmucosaassociatedlymphoidtissuelymphomaanarrativereview |