Molecular genetic approaches to decrease the uncontrolled misincorporation of non-canonical branched chain amino acids into recombinant mini-proinsulin expressed in Escherichia coli

The uncontrolled incorporation of non-canonical branched chain amino acids (ncBCAAs) such as norleucine, norvaline and β-methylnorleucine into recombinant proteins in E. coli production processes is a crucial problem in the pharmaceutical industry, since it can lead to the production of altered prot...

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Detalles Bibliográficos
Autores principales: García, Ángel Córcoles, Hauptmann, Peter, Neubauer, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8896088/
https://www.ncbi.nlm.nih.gov/pubmed/35246127
http://dx.doi.org/10.1186/s12934-022-01756-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8896088/
https://www.ncbi.nlm.nih.gov/pubmed/35246127
http://dx.doi.org/10.1186/s12934-022-01756-x

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