Tuberous sclerosis complex is a novel, amyloid-independent tauopathy associated with elevated phosphorylated 3R/4R tau aggregation

Tuberous sclerosis complex (TSC) is a neurodevelopmental disorder caused by mutations in the TSC1 and TSC2 genes and autosomal dominantly inherited. These mutations cause hyperactivation of the mammalian Target of Rapamycin (mTOR) pathway, leading to the development of nonmalignant masses involving...

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Detalles Bibliográficos
Autores principales: Liu, Andy J., Lusk, Jay B., Ervin, John, Burke, James, O’Brien, Richard, Wang, Shih-Hsiu J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8896101/
https://www.ncbi.nlm.nih.gov/pubmed/35241183
http://dx.doi.org/10.1186/s40478-022-01330-x

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