Vulvodynia Is Not Associated with Concurrent Candidal Vaginitis

Objective: The study purpose was to determine the prevalence of candida-positive vulvovaginal genital cultures among women with vulvodynia. Methods: This study was a retrospective analysis of data collected from 2017 to 2020. Eligible patients receiving care from an academic women's health practice in central Texas that employed value-based care pathways and who had a genital culture diagnostic test collected were included. Data were extracted from the electronic health record. Descriptive statistics, t-tests, and Fisher's exact test were used to complete the data analysis. Results: A total of 242 women met inclusion criteria and were included in the study. Of these, 64 (26.4%) had been diagnosed with vulvodynia and 178 (73.6%) had not. Of the 242 women, nearly one-third had confirmed yeast infections (29%) and 27 women (11%) met pathway criteria for polymerase chain reaction testing. There was no difference in the number of women with confirmed yeast infections during the study period among patients with or without a diagnosis of vulvodynia (75% vs. 70%, p = 0.718). Notably, among participants with vulvodynia, body mass index (BMI) was lower, and anxiety was more likely (t = 2.65, df = 120, p = 0.009; 78% vs. 55%, p = 0.002). Conclusions: The findings in this study showed no association between vulvodynia and yeast infection, a divergence from prior studies. In addition, vulvodynia was associated with low BMI and anxiety. Further research is needed to better understand the association between vulvovaginal candida infections and vulvodynia. Including women within and across more diverse races and ethnicities would improve generalizability.