Major vault protein attenuates cardiomyocyte injury in doxorubicin-induced cardiomyopathy through activating AKT

BACKGROUND: Doxorubicin (DOX) has limited chemotherapy application for malignancies due to cardiotoxicity. The pathogenesis of DOX-induced cardiomyopathy (DiCM) is yet to be elucidated. Increasing studies proved that activation of AKT prevented cardiomyocyte apoptosis and cardiac dysfunction in resp...

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Detalles Bibliográficos
Autores principales: Qi, Yu, Chen, Jianzhou, Duan, Junfeng, Kang, Lina, Wang, Kun, Chen, Ziwei, Xu, Biao, Gu, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8896232/
https://www.ncbi.nlm.nih.gov/pubmed/35246039
http://dx.doi.org/10.1186/s12872-022-02517-9

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