Domain-adaptive neural networks improve cross-species prediction of transcription factor binding

The intrinsic DNA sequence preferences and cell type–specific cooperative partners of transcription factors (TFs) are typically highly conserved. Hence, despite the rapid evolutionary turnover of individual TF binding sites, predictive sequence models of cell type–specific genomic occupancy of a TF...

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Detalles Bibliográficos
Autores principales: Cochran, Kelly, Srivastava, Divyanshi, Shrikumar, Avanti, Balsubramani, Akshay, Hardison, Ross C., Kundaje, Anshul, Mahony, Shaun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8896468/
https://www.ncbi.nlm.nih.gov/pubmed/35042722
http://dx.doi.org/10.1101/gr.275394.121

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