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The prevalence and outcomes of α- and β-thalassemia among pregnant women in Hubei Province, Central China: An observational study
There is no information concerning the prevalence of thalassemia among pregnant women in Hubei Province currently. This study is aimed to explore the prevalence of α- and β-thalassemia genotypes among pregnant women in Hubei Province, and to explore the clinically applicable screening approach, as w...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8896492/ https://www.ncbi.nlm.nih.gov/pubmed/35244037 http://dx.doi.org/10.1097/MD.0000000000028790 |
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author | Cheng, Yao Chen, Miaomiao Ye, Jiazhi Yang, Qin Wang, Ronggui Liu, Shulian Su, Rui Song, Jieping Gao, Tangxinzi Xu, Runhong Zhao, Feixia Zhang, Peili Sun, Guoqiang |
author_facet | Cheng, Yao Chen, Miaomiao Ye, Jiazhi Yang, Qin Wang, Ronggui Liu, Shulian Su, Rui Song, Jieping Gao, Tangxinzi Xu, Runhong Zhao, Feixia Zhang, Peili Sun, Guoqiang |
author_sort | Cheng, Yao |
collection | PubMed |
description | There is no information concerning the prevalence of thalassemia among pregnant women in Hubei Province currently. This study is aimed to explore the prevalence of α- and β-thalassemia genotypes among pregnant women in Hubei Province, and to explore the clinically applicable screening approach, as well as to investigate the pregnancy outcomes of α- and β-thalassemia carriers. Pregnant participants were recruited from 4 hospitals for the screening of α- and β-thalassemia mutations in Hubei Province. Polymerase Chain Reaction and flow cytometry methods were used to examine α- and β-thalassemia mutations. The hematological parameters and pregnancy outcomes of α- and β-thalassemia carriers were obtained from the hospital information system. The chi-square tests were used to evaluate the difference in hematological parameters between pregnant thalassemia carriers and the control group. Among 11,875 participants, 414 (3.49%) were confirmed with α-thalassemia carriers, 228 (1.92%) were confirmed with β-thalassemia carriers, and 3 (0.03%) were confirmed with both α- and β-thalassemia carriers. The frequency of –α(3.7) accounted for 2.05% and it was the most frequent genotype of α-thalassemia; the proportion of IVS-II-654 was 0.85% and it was the most frequent genotype of β-thalassemia in Hubei Province. Furthermore, the proportion of patients with low mean corpuscular volume (MCV) or mean cell hemoglobin (MCH) values was accounted for 36.64% and 93.97% among α-thalassemia and β-thalassemia carriers, respectively. And participants with normal MCV and MCH values were accounted for 95.07% among non-thalassemia participants. High prevalence of pregnancy-induced diabetes (16.97%), preterm birth (9.96%), pregnancy-induced hypertension (8.12%), and low birth weight (5.90%) were observed among pregnant thalassemia carriers. MCV and MCH values were suggested to apply on the preliminary screening of pregnant β-thalassemia; however, it's unpractical on that of α-thalassemia. Furthermore, thalassemia carriers might have a high risk of negative pregnancy outcomes. These findings could be useful for the preliminary screening of thalassemia and perinatal care for the pregnant thalassemia carriers. |
format | Online Article Text |
id | pubmed-8896492 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-88964922022-03-07 The prevalence and outcomes of α- and β-thalassemia among pregnant women in Hubei Province, Central China: An observational study Cheng, Yao Chen, Miaomiao Ye, Jiazhi Yang, Qin Wang, Ronggui Liu, Shulian Su, Rui Song, Jieping Gao, Tangxinzi Xu, Runhong Zhao, Feixia Zhang, Peili Sun, Guoqiang Medicine (Baltimore) 4400 There is no information concerning the prevalence of thalassemia among pregnant women in Hubei Province currently. This study is aimed to explore the prevalence of α- and β-thalassemia genotypes among pregnant women in Hubei Province, and to explore the clinically applicable screening approach, as well as to investigate the pregnancy outcomes of α- and β-thalassemia carriers. Pregnant participants were recruited from 4 hospitals for the screening of α- and β-thalassemia mutations in Hubei Province. Polymerase Chain Reaction and flow cytometry methods were used to examine α- and β-thalassemia mutations. The hematological parameters and pregnancy outcomes of α- and β-thalassemia carriers were obtained from the hospital information system. The chi-square tests were used to evaluate the difference in hematological parameters between pregnant thalassemia carriers and the control group. Among 11,875 participants, 414 (3.49%) were confirmed with α-thalassemia carriers, 228 (1.92%) were confirmed with β-thalassemia carriers, and 3 (0.03%) were confirmed with both α- and β-thalassemia carriers. The frequency of –α(3.7) accounted for 2.05% and it was the most frequent genotype of α-thalassemia; the proportion of IVS-II-654 was 0.85% and it was the most frequent genotype of β-thalassemia in Hubei Province. Furthermore, the proportion of patients with low mean corpuscular volume (MCV) or mean cell hemoglobin (MCH) values was accounted for 36.64% and 93.97% among α-thalassemia and β-thalassemia carriers, respectively. And participants with normal MCV and MCH values were accounted for 95.07% among non-thalassemia participants. High prevalence of pregnancy-induced diabetes (16.97%), preterm birth (9.96%), pregnancy-induced hypertension (8.12%), and low birth weight (5.90%) were observed among pregnant thalassemia carriers. MCV and MCH values were suggested to apply on the preliminary screening of pregnant β-thalassemia; however, it's unpractical on that of α-thalassemia. Furthermore, thalassemia carriers might have a high risk of negative pregnancy outcomes. These findings could be useful for the preliminary screening of thalassemia and perinatal care for the pregnant thalassemia carriers. Lippincott Williams & Wilkins 2022-03-04 /pmc/articles/PMC8896492/ /pubmed/35244037 http://dx.doi.org/10.1097/MD.0000000000028790 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) |
spellingShingle | 4400 Cheng, Yao Chen, Miaomiao Ye, Jiazhi Yang, Qin Wang, Ronggui Liu, Shulian Su, Rui Song, Jieping Gao, Tangxinzi Xu, Runhong Zhao, Feixia Zhang, Peili Sun, Guoqiang The prevalence and outcomes of α- and β-thalassemia among pregnant women in Hubei Province, Central China: An observational study |
title | The prevalence and outcomes of α- and β-thalassemia among pregnant women in Hubei Province, Central China: An observational study |
title_full | The prevalence and outcomes of α- and β-thalassemia among pregnant women in Hubei Province, Central China: An observational study |
title_fullStr | The prevalence and outcomes of α- and β-thalassemia among pregnant women in Hubei Province, Central China: An observational study |
title_full_unstemmed | The prevalence and outcomes of α- and β-thalassemia among pregnant women in Hubei Province, Central China: An observational study |
title_short | The prevalence and outcomes of α- and β-thalassemia among pregnant women in Hubei Province, Central China: An observational study |
title_sort | prevalence and outcomes of α- and β-thalassemia among pregnant women in hubei province, central china: an observational study |
topic | 4400 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8896492/ https://www.ncbi.nlm.nih.gov/pubmed/35244037 http://dx.doi.org/10.1097/MD.0000000000028790 |
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