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NPRL2 Inhibition of mTORC1 Controls Sodium Channel Expression and Brain Amino Acid Homeostasis
Genetic mutations in nitrogen permease regulator-like 2 (NPRL2) are associated with a wide spectrum of familial focal epilepsies, autism, and sudden unexpected death of epileptics (SUDEP), but the mechanisms by which NPRL2 contributes to these effects are not well known. NPRL2 is a requisite subunit...
Autores principales: | Hui, Jeremy B., Silva, Jose Cesar Hernandez, Pelaez, Mari Carmen, Sévigny, Myriam, Venkatasubramani, Janani Priya, Plumereau, Quentin, Chahine, Mohamed, Proulx, Christophe D., Sephton, Chantelle F., Dutchak, Paul A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Society for Neuroscience
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8896560/ https://www.ncbi.nlm.nih.gov/pubmed/35165201 http://dx.doi.org/10.1523/ENEURO.0317-21.2022 |
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