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Abrogation of self-tolerance by misfolded self-antigens complexed with MHC class II molecules

Specific MHC class II alleles are strongly associated with susceptibility to various autoimmune diseases. Although the primary function of MHC class II molecules is to present peptides to helper T cells, MHC class II molecules also function like a chaperone to transport misfolded intracellular prote...

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Detalles Bibliográficos
Autores principales:	Jin, Hui, Kishida, Kazuki, Arase, Noriko, Matsuoka, Sumiko, Nakai, Wataru, Kohyama, Masako, Suenaga, Tadahiro, Yamamoto, Ken, Sasazuki, Takehiko, Arase, Hisashi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8896794/ https://www.ncbi.nlm.nih.gov/pubmed/35245125 http://dx.doi.org/10.1126/sciadv.abj9867

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