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Cortico-striatal circuits for bilaterally coordinated movements

Movement initiation and control require the orchestrated activity of sensorimotor cortical and subcortical regions. However, the exact contribution of specific pathways and interactions to the final behavioral outcome are still under debate. Here, by combining structural lesions, pathway-specific op...

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Autores principales: Pimentel-Farfan, Ana K., Báez-Cordero, Ana S., Peña-Rangel, Teresa M., Rueda-Orozco, Pavel E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8896801/
https://www.ncbi.nlm.nih.gov/pubmed/35245127
http://dx.doi.org/10.1126/sciadv.abk2241
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author Pimentel-Farfan, Ana K.
Báez-Cordero, Ana S.
Peña-Rangel, Teresa M.
Rueda-Orozco, Pavel E.
author_facet Pimentel-Farfan, Ana K.
Báez-Cordero, Ana S.
Peña-Rangel, Teresa M.
Rueda-Orozco, Pavel E.
author_sort Pimentel-Farfan, Ana K.
collection PubMed
description Movement initiation and control require the orchestrated activity of sensorimotor cortical and subcortical regions. However, the exact contribution of specific pathways and interactions to the final behavioral outcome are still under debate. Here, by combining structural lesions, pathway-specific optogenetic manipulations and freely moving electrophysiological recordings in rats, we studied cortico-striatal interactions in the context of forelimb bilaterally coordinated movements. We provide evidence indicating that bilateral actions are initiated by motor cortical regions where intratelencephalic bilateral cortico-striatal (bcs-IT) projections recruit the sensorimotor striatum to provide stability and duration to already commanded bilateral movements. Furthermore, striatal spiking activity was correlated with movement duration and kinematic parameters of the execution. bcs-IT stimulation affected only the representation of movement duration but spared that of kinematics. Our findings confirm the modular organization of information processing in the striatum and its involvement in moment-to-moment movement control but not initiation or selection.
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spelling pubmed-88968012022-03-14 Cortico-striatal circuits for bilaterally coordinated movements Pimentel-Farfan, Ana K. Báez-Cordero, Ana S. Peña-Rangel, Teresa M. Rueda-Orozco, Pavel E. Sci Adv Neuroscience Movement initiation and control require the orchestrated activity of sensorimotor cortical and subcortical regions. However, the exact contribution of specific pathways and interactions to the final behavioral outcome are still under debate. Here, by combining structural lesions, pathway-specific optogenetic manipulations and freely moving electrophysiological recordings in rats, we studied cortico-striatal interactions in the context of forelimb bilaterally coordinated movements. We provide evidence indicating that bilateral actions are initiated by motor cortical regions where intratelencephalic bilateral cortico-striatal (bcs-IT) projections recruit the sensorimotor striatum to provide stability and duration to already commanded bilateral movements. Furthermore, striatal spiking activity was correlated with movement duration and kinematic parameters of the execution. bcs-IT stimulation affected only the representation of movement duration but spared that of kinematics. Our findings confirm the modular organization of information processing in the striatum and its involvement in moment-to-moment movement control but not initiation or selection. American Association for the Advancement of Science 2022-03-04 /pmc/articles/PMC8896801/ /pubmed/35245127 http://dx.doi.org/10.1126/sciadv.abk2241 Text en Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Neuroscience
Pimentel-Farfan, Ana K.
Báez-Cordero, Ana S.
Peña-Rangel, Teresa M.
Rueda-Orozco, Pavel E.
Cortico-striatal circuits for bilaterally coordinated movements
title Cortico-striatal circuits for bilaterally coordinated movements
title_full Cortico-striatal circuits for bilaterally coordinated movements
title_fullStr Cortico-striatal circuits for bilaterally coordinated movements
title_full_unstemmed Cortico-striatal circuits for bilaterally coordinated movements
title_short Cortico-striatal circuits for bilaterally coordinated movements
title_sort cortico-striatal circuits for bilaterally coordinated movements
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8896801/
https://www.ncbi.nlm.nih.gov/pubmed/35245127
http://dx.doi.org/10.1126/sciadv.abk2241
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