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Galvanic current activates the NLRP3 inflammasome to promote Type I collagen production in tendon

The NLRP3 inflammasome coordinates inflammation in response to different pathogen- and damage-associated molecular patterns, being implicated in different infectious, chronic inflammatory, metabolic and degenerative diseases. In chronic tendinopathic lesions, different non-resolving mechanisms produ...

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Detalles Bibliográficos
Autores principales: Peñin-Franch, Alejandro, García-Vidal, José Antonio, Martínez, Carlos Manuel, Escolar-Reina, Pilar, Martínez-Ojeda, Rosa M, Gómez, Ana I, Bueno, Juan M, Minaya-Muñoz, Francisco, Valera-Garrido, Fermín, Medina-Mirapeix, Francesc, Pelegrín, Pablo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8896827/
https://www.ncbi.nlm.nih.gov/pubmed/35199642
http://dx.doi.org/10.7554/eLife.73675
Descripción
Sumario:The NLRP3 inflammasome coordinates inflammation in response to different pathogen- and damage-associated molecular patterns, being implicated in different infectious, chronic inflammatory, metabolic and degenerative diseases. In chronic tendinopathic lesions, different non-resolving mechanisms produce a degenerative condition that impairs tissue healing and which therefore complicates their clinical management. Percutaneous needle electrolysis consists of the application of a galvanic current and is an emerging treatment for tendinopathies. In the present study, we found that galvanic current activates the NLRP3 inflammasome and induces an inflammatory response that promotes a collagen-mediated regeneration of the tendon in mice. This study establishes the molecular mechanism of percutaneous electrolysis that can be used to treat chronic lesions and describes the beneficial effects of an induced inflammasome-related response.