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An Unusual Case of Chronic Lymphocytic Leukaemia Involving the Cervix

Chronic lymphocytic leukaemia (CLL) is a malignant monoclonal expansion of B lymphocytes, with accumulation of abnormal lymphocytes in the blood, bone marrow, spleen, lymph nodes and liver. It is mainly a disease of the elderly population. Though extra-nodal involvement is common, cervical and vulvo...

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Detalles Bibliográficos
Autores principales: Hamer, Jack, Alazizi, Maher, Tahmasebi, Farshad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8896842/
https://www.ncbi.nlm.nih.gov/pubmed/35291544
http://dx.doi.org/10.7759/cureus.21823
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author Hamer, Jack
Alazizi, Maher
Tahmasebi, Farshad
author_facet Hamer, Jack
Alazizi, Maher
Tahmasebi, Farshad
author_sort Hamer, Jack
collection PubMed
description Chronic lymphocytic leukaemia (CLL) is a malignant monoclonal expansion of B lymphocytes, with accumulation of abnormal lymphocytes in the blood, bone marrow, spleen, lymph nodes and liver. It is mainly a disease of the elderly population. Though extra-nodal involvement is common, cervical and vulvovaginal involvement by CLL is particularly uncommon. In this case report, we discuss the case of cervical involvement of CLL in an 84-year-old patient who presented to rapid-access gynaecological clinic following concerns of persistent postmenopausal bleeding. Previously the patient was known to haematology with a well-controlled diagnosis of CLL since 2007. The initial examination was significant for an enlarged, irregular cervix, whereby a punch biopsy was then obtained. Histological analysis revealed evidence of CLL within the cervix.
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spelling pubmed-88968422022-03-14 An Unusual Case of Chronic Lymphocytic Leukaemia Involving the Cervix Hamer, Jack Alazizi, Maher Tahmasebi, Farshad Cureus Obstetrics/Gynecology Chronic lymphocytic leukaemia (CLL) is a malignant monoclonal expansion of B lymphocytes, with accumulation of abnormal lymphocytes in the blood, bone marrow, spleen, lymph nodes and liver. It is mainly a disease of the elderly population. Though extra-nodal involvement is common, cervical and vulvovaginal involvement by CLL is particularly uncommon. In this case report, we discuss the case of cervical involvement of CLL in an 84-year-old patient who presented to rapid-access gynaecological clinic following concerns of persistent postmenopausal bleeding. Previously the patient was known to haematology with a well-controlled diagnosis of CLL since 2007. The initial examination was significant for an enlarged, irregular cervix, whereby a punch biopsy was then obtained. Histological analysis revealed evidence of CLL within the cervix. Cureus 2022-02-01 /pmc/articles/PMC8896842/ /pubmed/35291544 http://dx.doi.org/10.7759/cureus.21823 Text en Copyright © 2022, Hamer et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Obstetrics/Gynecology
Hamer, Jack
Alazizi, Maher
Tahmasebi, Farshad
An Unusual Case of Chronic Lymphocytic Leukaemia Involving the Cervix
title An Unusual Case of Chronic Lymphocytic Leukaemia Involving the Cervix
title_full An Unusual Case of Chronic Lymphocytic Leukaemia Involving the Cervix
title_fullStr An Unusual Case of Chronic Lymphocytic Leukaemia Involving the Cervix
title_full_unstemmed An Unusual Case of Chronic Lymphocytic Leukaemia Involving the Cervix
title_short An Unusual Case of Chronic Lymphocytic Leukaemia Involving the Cervix
title_sort unusual case of chronic lymphocytic leukaemia involving the cervix
topic Obstetrics/Gynecology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8896842/
https://www.ncbi.nlm.nih.gov/pubmed/35291544
http://dx.doi.org/10.7759/cureus.21823
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