Activation of the Innate Immune Checkpoint CLEC5A on Myeloid Cells in the Absence of Danger Signals Modulates Macrophages' Function but Does Not Trigger the Adaptive T Cell Immune Response

C-Type lectin receptor 5A (CLEC5A) is a spleen tyrosine kinase- (Syk-) coupled pattern recognition receptor expressed on myeloid cells and involved in the innate immune response to viral and bacterial infections. Activation of the CLEC5A receptor with pathogen-derived antigens leads to a secretion o...

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Detalles Bibliográficos
Autores principales: Tosiek, Milena J., Groesser, Kerstin, Pekcec, Anton, Zwirek, Monika, Murugesan, Gavuthami, Borges, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8896916/
https://www.ncbi.nlm.nih.gov/pubmed/35252461
http://dx.doi.org/10.1155/2022/9926305

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