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Effect and Mechanisms of Quercetin for Experimental Focal Cerebral Ischemia: A Systematic Review and Meta-Analysis

Quercetin, a naturally occurring flavonoid, is mainly extracted from tea, onions, and apples. It has the underlying neuroprotective effect on experimental ischemic stroke. A systematic review and meta-analysis were used to assess quercetin's efficacy and possible mechanisms in treating focal ce...

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Autores principales: Guo, Chao, Wang, Wen-Jun, Liao, Yu-Cheng, Zhao, Chao, Yin, Ying, Yao, Min-Na, Ding, Yi, Wang, Jing-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8896934/
https://www.ncbi.nlm.nih.gov/pubmed/35251482
http://dx.doi.org/10.1155/2022/9749461
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author Guo, Chao
Wang, Wen-Jun
Liao, Yu-Cheng
Zhao, Chao
Yin, Ying
Yao, Min-Na
Ding, Yi
Wang, Jing-Wen
author_facet Guo, Chao
Wang, Wen-Jun
Liao, Yu-Cheng
Zhao, Chao
Yin, Ying
Yao, Min-Na
Ding, Yi
Wang, Jing-Wen
author_sort Guo, Chao
collection PubMed
description Quercetin, a naturally occurring flavonoid, is mainly extracted from tea, onions, and apples. It has the underlying neuroprotective effect on experimental ischemic stroke. A systematic review and meta-analysis were used to assess quercetin's efficacy and possible mechanisms in treating focal cerebral ischemia. Compared with the control group, twelve studies reported a remarkable function of quercetin in improving the neurological function score (NFS) (P < 0.05), and twelve studies reported a significant effect on reducing infarct volume (P < 0.05). Moreover, two and three studies showed that quercetin could alleviate blood-brain barrier (BBB) permeability and brain water content, respectively. The mechanisms of quercetin against focal cerebral ischemia are diverse, involving antioxidation, antiapoptotic, anti-inflammation, and calcium overload reduction. On the whole, the present study suggested that quercetin can exert a protective effect on experimental ischemic stroke. Although the effect size may be overestimated because of the quality of studies and possible publication bias, these results indicated that quercetin might be a promising neuroprotective agent for human ischemic stroke. This study is registered with PROSPERO, number CRD 42021275656.
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spelling pubmed-88969342022-03-05 Effect and Mechanisms of Quercetin for Experimental Focal Cerebral Ischemia: A Systematic Review and Meta-Analysis Guo, Chao Wang, Wen-Jun Liao, Yu-Cheng Zhao, Chao Yin, Ying Yao, Min-Na Ding, Yi Wang, Jing-Wen Oxid Med Cell Longev Review Article Quercetin, a naturally occurring flavonoid, is mainly extracted from tea, onions, and apples. It has the underlying neuroprotective effect on experimental ischemic stroke. A systematic review and meta-analysis were used to assess quercetin's efficacy and possible mechanisms in treating focal cerebral ischemia. Compared with the control group, twelve studies reported a remarkable function of quercetin in improving the neurological function score (NFS) (P < 0.05), and twelve studies reported a significant effect on reducing infarct volume (P < 0.05). Moreover, two and three studies showed that quercetin could alleviate blood-brain barrier (BBB) permeability and brain water content, respectively. The mechanisms of quercetin against focal cerebral ischemia are diverse, involving antioxidation, antiapoptotic, anti-inflammation, and calcium overload reduction. On the whole, the present study suggested that quercetin can exert a protective effect on experimental ischemic stroke. Although the effect size may be overestimated because of the quality of studies and possible publication bias, these results indicated that quercetin might be a promising neuroprotective agent for human ischemic stroke. This study is registered with PROSPERO, number CRD 42021275656. Hindawi 2022-02-25 /pmc/articles/PMC8896934/ /pubmed/35251482 http://dx.doi.org/10.1155/2022/9749461 Text en Copyright © 2022 Chao Guo et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Guo, Chao
Wang, Wen-Jun
Liao, Yu-Cheng
Zhao, Chao
Yin, Ying
Yao, Min-Na
Ding, Yi
Wang, Jing-Wen
Effect and Mechanisms of Quercetin for Experimental Focal Cerebral Ischemia: A Systematic Review and Meta-Analysis
title Effect and Mechanisms of Quercetin for Experimental Focal Cerebral Ischemia: A Systematic Review and Meta-Analysis
title_full Effect and Mechanisms of Quercetin for Experimental Focal Cerebral Ischemia: A Systematic Review and Meta-Analysis
title_fullStr Effect and Mechanisms of Quercetin for Experimental Focal Cerebral Ischemia: A Systematic Review and Meta-Analysis
title_full_unstemmed Effect and Mechanisms of Quercetin for Experimental Focal Cerebral Ischemia: A Systematic Review and Meta-Analysis
title_short Effect and Mechanisms of Quercetin for Experimental Focal Cerebral Ischemia: A Systematic Review and Meta-Analysis
title_sort effect and mechanisms of quercetin for experimental focal cerebral ischemia: a systematic review and meta-analysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8896934/
https://www.ncbi.nlm.nih.gov/pubmed/35251482
http://dx.doi.org/10.1155/2022/9749461
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