Cargando…

Understanding the physiological functions of the host xenobiotic-sensing nuclear receptors PXR and CAR on the gut microbiome using genetically modified mice

Pharmacological activation of the xenobiotic-sensing nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) is well-known to increase drug metabolism and reduce inflammation. Little is known regarding their physiological functions on the gut microbiome. In this study,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Little, Mallory, Dutta, Moumita, Li, Hao, Matson, Adam, Shi, Xiaojian, Mascarinas, Gabby, Molla, Bruk, Weigel, Kris, Gu, Haiwei, Mani, Sridhar, Cui, Julia Yue
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897037/ https://www.ncbi.nlm.nih.gov/pubmed/35256948 http://dx.doi.org/10.1016/j.apsb.2021.07.022

Ejemplares similares

A brief history of the discovery of PXR and CAR as xenobiotic receptors
por: Yan, Jiong, et al.
Publicado: (2016)

Pcsk9 Deletion Promotes Murine Nonalcoholic Steatohepatitis and Hepatic Carcinogenesis: Role of Cholesterol
por: Ioannou, George N., et al.
Publicado: (2021)

Regulation of CAR and PXR Expression in Health and Disease
por: Daujat-Chavanieu, Martine, et al.
Publicado: (2020)

Polychlorinated biphenyls altered gut microbiome in CAR and PXR knockout mice exhibiting toxicant-associated steatohepatitis
por: Wahlang, Banrida, et al.
Publicado: (2021)

Association of PXR and CAR Polymorphisms and Antituberculosis Drug-Induced Hepatotoxicity
por: Wang, Yu, et al.
Publicado: (2019)

Impact of genetic polymorphisms of drug transporters ABCB1 and ABCG2 and regulators of xenobiotic transport and metabolism PXR and CAR on clinical efficacy of dasatinib in chronic myeloid leukemia
por: Madejczyk, Anna Marta, et al.
Publicado: (2022)

Epidermal Overexpression of Xenobiotic Receptor PXR Impairs the Epidermal Barrier and Triggers Th2 Immune Response
por: Elentner, Andreas, et al.
Publicado: (2017)

Targeting the PXR-TLR4 signaling pathway to reduce intestinal inflammation in an experimental model of necrotizing enterocolitis
por: Huang, Kezhen, et al.
Publicado: (2018)

Xenobiotic Metabolism and Gut Microbiomes
por: Das, Anubhav, et al.
Publicado: (2016)

Xenobiotic-Induced Hepatocyte Proliferation Associated with Constitutive Active/Androstane Receptor (CAR) or Peroxisome Proliferator-Activated Receptor α (PPARα) Is Enhanced by Pregnane X Receptor (PXR) Activation in Mice
por: Shizu, Ryota, et al.
Publicado: (2013)

Antiretroviral Drug Metabolism in Humanized PXR-CAR-CYP3A-NOG Mice
por: McMillan, JoEllyn M., et al.
Publicado: (2018)

The gut microbiome: an orchestrator of xenobiotic metabolism
por: Collins, Stephanie L., et al.
Publicado: (2020)

The xenobiotic sensing pregnane X receptor regulates tissue damage and inflammation triggered by C difficile toxins
por: Erickson, Sarah L., et al.
Publicado: (2019)

Activation of PXR by Alpinetin Contributes to Abrogate Chemically Induced Inflammatory Bowel Disease
por: Yu, Zhilun, et al.
Publicado: (2020)

Activation of PXR, CAR and PPARα by pyrethroid pesticides and the effect of metabolism by rat liver microsomes
por: Fujino, Chieri, et al.
Publicado: (2019)

Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation
por: Bwayi, Monicah N, et al.
Publicado: (2022)

Alleviation of Gut Inflammation by Cdx2/Pxr Pathway in a Mouse Model of Chemical Colitis
por: Dou, Wei, et al.
Publicado: (2012)

Evaluating the Role of the Steroid and Xenobiotic Receptor (SXR/PXR) in PCB-153 Metabolism and Protection against Associated Adverse Effects during Perinatal and Chronic Exposure in Mice
por: Egusquiza, Riann Jenay, et al.
Publicado: (2020)

Complex effects of rexinoids on ligand dependent activation or inhibition of the xenobiotic receptor, CAR
por: Tzameli, Iphigenia, et al.
Publicado: (2003)

PXR and CAR single nucleotide polymorphisms influence plasma efavirenz levels in South African HIV/AIDS patients
por: Swart, Marelize, et al.
Publicado: (2012)

Transactivation Assays to Assess Canine and Rodent Pregnane X Receptor (PXR) and Constitutive Androstane Receptor (CAR) Activation
por: Pinne, Marija, et al.
Publicado: (2016)

Regulation of High-Altitude Hypoxia on the Transcription of CYP450 and UGT1A1 Mediated by PXR and CAR
por: Duan, Ya-bin, et al.
Publicado: (2020)

Phenobarbital Induces SLC13A5 Expression through Activation of PXR but Not CAR in Human Primary Hepatocytes
por: Li, Zhihui, et al.
Publicado: (2021)

Erratum: “Evaluating the Role of the Steroid and Xenobiotic Receptor (SXR/PXR) in PCB-153 Metabolism and Protection against Associated Adverse Effects during Perinatal and Chronic Exposure in Mice”
por: Egusquiza, Riann Jenay, et al.
Publicado: (2020)

Xenobiotic Receptor-Mediated Regulation of Intestinal Barrier Function and Innate Immunity
por: Ranhotra, Harmit S., et al.
Publicado: (2016)

Species-specific regulation of PXR/CAR/ER-target genes in the mouse and rat liver elicited by o, p'-DDT
por: Kiyosawa, Naoki, et al.
Publicado: (2008)

Toxicomicrobiomics: The Human Microbiome vs. Pharmaceutical, Dietary, and Environmental Xenobiotics
por: Abdelsalam, Nehal Adel, et al.
Publicado: (2020)

Microbiota analysis for risk assessment of xenobiotics: toxicomicrobiomics, incorporating the gut microbiome in the risk assessment of xenobiotics and identifying beneficial components for One Health
por: Ampatzoglou, Antonios, et al.
Publicado: (2022)

Interleukin-6 Induces DEC1, Promotes DEC1 Interaction with RXRα and Suppresses the Expression of PXR, CAR and Their Target Genes
por: Ning, Rui, et al.
Publicado: (2017)

ChIPing the cistrome of PXR in mouse liver
por: Cui, Julia Yue, et al.
Publicado: (2010)

Biology of PXR: role in drug-hormone interactions
por: Wang, Jing, et al.
Publicado: (2014)

PXR is a target of (-)-epicatechin in skeletal muscle
por: Ortiz-Flores, Miguel, et al.
Publicado: (2020)

PXR: a center of transcriptional regulation in cancer
por: Xing, Yaqi, et al.
Publicado: (2020)

Nuclear Receptor PXR in Drug-Induced Hypercholesterolemia
por: Karpale, Mikko, et al.
Publicado: (2022)

The Nuclear Receptor PXR in Chronic Liver Disease
por: Sayaf, Katia, et al.
Publicado: (2021)

PXR as a mediator of herb–drug interaction
por: Hogle, Brett C., et al.
Publicado: (2017)

The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism
por: Zhou, Changcheng, et al.
Publicado: (2009)

“Commandeuring” Xenobiotic Metabolism: Advances in Understanding Xenobiotic Metabolism
por: van Vugt-Lussenburg, Barbara M. A., et al.
Publicado: (2022)

Pregnane X Receptor (PXR)-Mediated Gene Repression and Cross-Talk of PXR with Other Nuclear Receptors via Coactivator Interactions
por: Pavek, Petr
Publicado: (2016)

The 3ʹ-untranslated region contributes to the pregnane X receptor (PXR) expression down-regulation by PXR ligands and up-regulation by glucocorticoids
por: Smutny, Tomas, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_0k2roaspb79anmvilck60qkgbc