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Biomaterial scaffolds for clinical procedures in endodontic regeneration

Regenerative endodontic procedures have been rapidly evolving over the past two decades and are employed extensively in clinical endodontics. These procedures have been perceived as valuable adjuvants to conventional strategies in the treatment of necrotic immature permanent teeth that were deemed t...

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Detalles Bibliográficos
Autores principales: Liu, He, Lu, Jing, Jiang, Qianzhou, Haapasalo, Markus, Qian, Junrong, Tay, Franklin R., Shen, Ya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897058/
https://www.ncbi.nlm.nih.gov/pubmed/35310382
http://dx.doi.org/10.1016/j.bioactmat.2021.10.008
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author Liu, He
Lu, Jing
Jiang, Qianzhou
Haapasalo, Markus
Qian, Junrong
Tay, Franklin R.
Shen, Ya
author_facet Liu, He
Lu, Jing
Jiang, Qianzhou
Haapasalo, Markus
Qian, Junrong
Tay, Franklin R.
Shen, Ya
author_sort Liu, He
collection PubMed
description Regenerative endodontic procedures have been rapidly evolving over the past two decades and are employed extensively in clinical endodontics. These procedures have been perceived as valuable adjuvants to conventional strategies in the treatment of necrotic immature permanent teeth that were deemed to have poor prognosis. As a component biological triad of tissue engineering (i.e., stem cells, growth factors and scaffolds), biomaterial scaffolds have demonstrated clinical potential as an armamentarium in regenerative endodontic procedures and achieved remarkable advancements. The aim of the present review is to provide a broad overview of biomaterials employed for scaffolding in regenerative endodontics. The favorable properties and limitations of biomaterials organized in naturally derived, host-derived and synthetic material categories were discussed. Preclinical and clinical studies published over the past five years on the performance of biomaterial scaffolds, as well as current challenges and future perspectives for the application of biomaterials for scaffolding and clinical evaluation of biomaterial scaffolds in regenerative endodontic procedures were addressed in depth.
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spelling pubmed-88970582022-03-17 Biomaterial scaffolds for clinical procedures in endodontic regeneration Liu, He Lu, Jing Jiang, Qianzhou Haapasalo, Markus Qian, Junrong Tay, Franklin R. Shen, Ya Bioact Mater Article Regenerative endodontic procedures have been rapidly evolving over the past two decades and are employed extensively in clinical endodontics. These procedures have been perceived as valuable adjuvants to conventional strategies in the treatment of necrotic immature permanent teeth that were deemed to have poor prognosis. As a component biological triad of tissue engineering (i.e., stem cells, growth factors and scaffolds), biomaterial scaffolds have demonstrated clinical potential as an armamentarium in regenerative endodontic procedures and achieved remarkable advancements. The aim of the present review is to provide a broad overview of biomaterials employed for scaffolding in regenerative endodontics. The favorable properties and limitations of biomaterials organized in naturally derived, host-derived and synthetic material categories were discussed. Preclinical and clinical studies published over the past five years on the performance of biomaterial scaffolds, as well as current challenges and future perspectives for the application of biomaterials for scaffolding and clinical evaluation of biomaterial scaffolds in regenerative endodontic procedures were addressed in depth. KeAi Publishing 2021-10-14 /pmc/articles/PMC8897058/ /pubmed/35310382 http://dx.doi.org/10.1016/j.bioactmat.2021.10.008 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Liu, He
Lu, Jing
Jiang, Qianzhou
Haapasalo, Markus
Qian, Junrong
Tay, Franklin R.
Shen, Ya
Biomaterial scaffolds for clinical procedures in endodontic regeneration
title Biomaterial scaffolds for clinical procedures in endodontic regeneration
title_full Biomaterial scaffolds for clinical procedures in endodontic regeneration
title_fullStr Biomaterial scaffolds for clinical procedures in endodontic regeneration
title_full_unstemmed Biomaterial scaffolds for clinical procedures in endodontic regeneration
title_short Biomaterial scaffolds for clinical procedures in endodontic regeneration
title_sort biomaterial scaffolds for clinical procedures in endodontic regeneration
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897058/
https://www.ncbi.nlm.nih.gov/pubmed/35310382
http://dx.doi.org/10.1016/j.bioactmat.2021.10.008
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