Validation of a Novel Renal Denervation System With Cryoablation: A Preclinical Study and Case Series

Recently, we designed a renal denervation with cryoablation (Cryo-RDN) system using liquid nitrogen and proved its short-term safety and effectiveness. In this study, we first conducted a 6-month follow-up in a swine model. Renal sympathetic nerve activity remained at a significantly lower level tha...

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Detalles Bibliográficos
Autores principales: Ji, Meng, Chen, Han, Shen, Li, Zhang, Yi, Yao, Zhifeng, Wu, Yizhe, Xu, Yawei, Ge, Junbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Clinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897167/
https://www.ncbi.nlm.nih.gov/pubmed/35257036
http://dx.doi.org/10.1016/j.jacbts.2021.11.002
Descripción
Sumario:Recently, we designed a renal denervation with cryoablation (Cryo-RDN) system using liquid nitrogen and proved its short-term safety and effectiveness. In this study, we first conducted a 6-month follow-up in a swine model. Renal sympathetic nerve activity remained at a significantly lower level than that of the control group after 6 months. In patients with resistant hypertension, Cryo-RDN demonstrated preliminary safety. Renal function fluctuations and vascular-related complications were not detected. In addition, the average 24-hour systolic and diastolic blood pressure decreased by 12.17 ± 8.35 mm Hg and 8.50 ± 3.83 mm Hg at the 6-month follow-up, respectively, compared with their baseline values.

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