Validation of a Novel Renal Denervation System With Cryoablation: A Preclinical Study and Case Series

Recently, we designed a renal denervation with cryoablation (Cryo-RDN) system using liquid nitrogen and proved its short-term safety and effectiveness. In this study, we first conducted a 6-month follow-up in a swine model. Renal sympathetic nerve activity remained at a significantly lower level tha...

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Detalles Bibliográficos
Autores principales: Ji, Meng, Chen, Han, Shen, Li, Zhang, Yi, Yao, Zhifeng, Wu, Yizhe, Xu, Yawei, Ge, Junbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Clinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897167/
https://www.ncbi.nlm.nih.gov/pubmed/35257036
http://dx.doi.org/10.1016/j.jacbts.2021.11.002
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author Ji, Meng
Chen, Han
Shen, Li
Zhang, Yi
Yao, Zhifeng
Wu, Yizhe
Xu, Yawei
Ge, Junbo
author_facet Ji, Meng
Chen, Han
Shen, Li
Zhang, Yi
Yao, Zhifeng
Wu, Yizhe
Xu, Yawei
Ge, Junbo
author_sort Ji, Meng
collection PubMed
description Recently, we designed a renal denervation with cryoablation (Cryo-RDN) system using liquid nitrogen and proved its short-term safety and effectiveness. In this study, we first conducted a 6-month follow-up in a swine model. Renal sympathetic nerve activity remained at a significantly lower level than that of the control group after 6 months. In patients with resistant hypertension, Cryo-RDN demonstrated preliminary safety. Renal function fluctuations and vascular-related complications were not detected. In addition, the average 24-hour systolic and diastolic blood pressure decreased by 12.17 ± 8.35 mm Hg and 8.50 ± 3.83 mm Hg at the 6-month follow-up, respectively, compared with their baseline values.
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spelling pubmed-88971672022-03-06 Validation of a Novel Renal Denervation System With Cryoablation: A Preclinical Study and Case Series Ji, Meng Chen, Han Shen, Li Zhang, Yi Yao, Zhifeng Wu, Yizhe Xu, Yawei Ge, Junbo JACC Basic Transl Sci Clinical Research Recently, we designed a renal denervation with cryoablation (Cryo-RDN) system using liquid nitrogen and proved its short-term safety and effectiveness. In this study, we first conducted a 6-month follow-up in a swine model. Renal sympathetic nerve activity remained at a significantly lower level than that of the control group after 6 months. In patients with resistant hypertension, Cryo-RDN demonstrated preliminary safety. Renal function fluctuations and vascular-related complications were not detected. In addition, the average 24-hour systolic and diastolic blood pressure decreased by 12.17 ± 8.35 mm Hg and 8.50 ± 3.83 mm Hg at the 6-month follow-up, respectively, compared with their baseline values. Elsevier 2022-02-02 /pmc/articles/PMC8897167/ /pubmed/35257036 http://dx.doi.org/10.1016/j.jacbts.2021.11.002 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Clinical Research
Ji, Meng
Chen, Han
Shen, Li
Zhang, Yi
Yao, Zhifeng
Wu, Yizhe
Xu, Yawei
Ge, Junbo
Validation of a Novel Renal Denervation System With Cryoablation: A Preclinical Study and Case Series
title Validation of a Novel Renal Denervation System With Cryoablation: A Preclinical Study and Case Series
title_full Validation of a Novel Renal Denervation System With Cryoablation: A Preclinical Study and Case Series
title_fullStr Validation of a Novel Renal Denervation System With Cryoablation: A Preclinical Study and Case Series
title_full_unstemmed Validation of a Novel Renal Denervation System With Cryoablation: A Preclinical Study and Case Series
title_short Validation of a Novel Renal Denervation System With Cryoablation: A Preclinical Study and Case Series
title_sort validation of a novel renal denervation system with cryoablation: a preclinical study and case series
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897167/
https://www.ncbi.nlm.nih.gov/pubmed/35257036
http://dx.doi.org/10.1016/j.jacbts.2021.11.002
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