Mixed infection by Cryptococcus neoformans and Cryptococcus gattii and coinfection with paracoccidioidomycosis in PLHIV

We present a rare condition of mixed C. neoformans and C. gattii infection in a person living with HIV with false-negative CrAg LFA in the CSF and co-infection with paracoccidioidomycosis. Signs and symptoms are relative to respiratory tract and skin, confounding with other opportunistic disease. Af...

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Autores principales: de Faria Ferreira, Marcela, Brito-Santos, Fabio, Henrique Nascimento Theodoro, Pedro, de Abreu Almeida, Marcos, Lazera, Marcia dos Santos, Trilles, Luciana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897171/
https://www.ncbi.nlm.nih.gov/pubmed/35256962
http://dx.doi.org/10.1016/j.mmcr.2022.01.006
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author de Faria Ferreira, Marcela
Brito-Santos, Fabio
Henrique Nascimento Theodoro, Pedro
de Abreu Almeida, Marcos
Lazera, Marcia dos Santos
Trilles, Luciana
author_facet de Faria Ferreira, Marcela
Brito-Santos, Fabio
Henrique Nascimento Theodoro, Pedro
de Abreu Almeida, Marcos
Lazera, Marcia dos Santos
Trilles, Luciana
author_sort de Faria Ferreira, Marcela
collection PubMed
description We present a rare condition of mixed C. neoformans and C. gattii infection in a person living with HIV with false-negative CrAg LFA in the CSF and co-infection with paracoccidioidomycosis. Signs and symptoms are relative to respiratory tract and skin, confounding with other opportunistic disease. After negatives CrAg LFA and Indian ink staining in CSF, there was isolation of C. gattii in sputum and C. neoformans in CSF, in addition to reagent serology (double immunodiffusion) for PCM with 1/16 titer. The patient was treated with amphotericin B and TMP-SMX with good clinical response and recovery of cellular immunity after initiation of antiretroviral therapy.
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spelling pubmed-88971712022-03-06 Mixed infection by Cryptococcus neoformans and Cryptococcus gattii and coinfection with paracoccidioidomycosis in PLHIV de Faria Ferreira, Marcela Brito-Santos, Fabio Henrique Nascimento Theodoro, Pedro de Abreu Almeida, Marcos Lazera, Marcia dos Santos Trilles, Luciana Med Mycol Case Rep Case Report We present a rare condition of mixed C. neoformans and C. gattii infection in a person living with HIV with false-negative CrAg LFA in the CSF and co-infection with paracoccidioidomycosis. Signs and symptoms are relative to respiratory tract and skin, confounding with other opportunistic disease. After negatives CrAg LFA and Indian ink staining in CSF, there was isolation of C. gattii in sputum and C. neoformans in CSF, in addition to reagent serology (double immunodiffusion) for PCM with 1/16 titer. The patient was treated with amphotericin B and TMP-SMX with good clinical response and recovery of cellular immunity after initiation of antiretroviral therapy. Elsevier 2022-01-27 /pmc/articles/PMC8897171/ /pubmed/35256962 http://dx.doi.org/10.1016/j.mmcr.2022.01.006 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
de Faria Ferreira, Marcela
Brito-Santos, Fabio
Henrique Nascimento Theodoro, Pedro
de Abreu Almeida, Marcos
Lazera, Marcia dos Santos
Trilles, Luciana
Mixed infection by Cryptococcus neoformans and Cryptococcus gattii and coinfection with paracoccidioidomycosis in PLHIV
title Mixed infection by Cryptococcus neoformans and Cryptococcus gattii and coinfection with paracoccidioidomycosis in PLHIV
title_full Mixed infection by Cryptococcus neoformans and Cryptococcus gattii and coinfection with paracoccidioidomycosis in PLHIV
title_fullStr Mixed infection by Cryptococcus neoformans and Cryptococcus gattii and coinfection with paracoccidioidomycosis in PLHIV
title_full_unstemmed Mixed infection by Cryptococcus neoformans and Cryptococcus gattii and coinfection with paracoccidioidomycosis in PLHIV
title_short Mixed infection by Cryptococcus neoformans and Cryptococcus gattii and coinfection with paracoccidioidomycosis in PLHIV
title_sort mixed infection by cryptococcus neoformans and cryptococcus gattii and coinfection with paracoccidioidomycosis in plhiv
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897171/
https://www.ncbi.nlm.nih.gov/pubmed/35256962
http://dx.doi.org/10.1016/j.mmcr.2022.01.006
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