Targeting a cryptic allosteric site of SIRT6 with small-molecule inhibitors that inhibit the migration of pancreatic cancer cells

SIRT6 belongs to the conserved NAD(+)-dependent deacetylase superfamily and mediates multiple biological and pathological processes. Targeting SIRT6 by allosteric modulators represents a novel direction for therapeutics, which can overcome the selectivity problem caused by the structural similarity...

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Detalles Bibliográficos
Autores principales: Zhang, Qiufen, Chen, Yingyi, Ni, Duan, Huang, Zhimin, Wei, Jiacheng, Feng, Li, Su, Jun-Cheng, Wei, Yingqing, Ning, Shaobo, Yang, Xiuyan, Zhao, Mingzhu, Qiu, Yuran, Song, Kun, Yu, Zhengtian, Xu, Jianrong, Li, Xinyi, Lin, Houwen, Lu, Shaoyong, Zhang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897208/
https://www.ncbi.nlm.nih.gov/pubmed/35256952
http://dx.doi.org/10.1016/j.apsb.2021.06.015

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