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A Diverse Spectrum of Immune Complex– and Complement-Mediated Kidney Diseases Is Associated With Mantle Cell Lymphoma

INTRODUCTION: There are limited reports on kidney biopsy findings in patients with mantle cell lymphoma (MCL). METHODS: We initiated a multi-institutional, retrospective review of kidney biopsy findings in patients with active and treated MCL. RESULTS: A total of 30 patients with MCL and kidney biop...

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Autores principales: Andeen, Nicole K., Abdulameer, Shahad, Charu, Vivek, Zuckerman, Jonathan E., Troxell, Megan, Kambham, Neeraja, Alpers, Charles E., Najafian, Behzad, Nicosia, Roberto F., Smith, Kelly D., Kung, Vanderlene L., Avasare, Rupali S., Vallurupalli, Anusha, Jefferson, J. Ashley, Hecox, Douglas, Swetnam, Leah, Yamashita, Michifumi, Lin, Mercury, Bissonnette, Mei Lin, Akilesh, Shreeram, Hou, Jean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897291/
https://www.ncbi.nlm.nih.gov/pubmed/35257069
http://dx.doi.org/10.1016/j.ekir.2021.12.020
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author Andeen, Nicole K.
Abdulameer, Shahad
Charu, Vivek
Zuckerman, Jonathan E.
Troxell, Megan
Kambham, Neeraja
Alpers, Charles E.
Najafian, Behzad
Nicosia, Roberto F.
Smith, Kelly D.
Kung, Vanderlene L.
Avasare, Rupali S.
Vallurupalli, Anusha
Jefferson, J. Ashley
Hecox, Douglas
Swetnam, Leah
Yamashita, Michifumi
Lin, Mercury
Bissonnette, Mei Lin
Akilesh, Shreeram
Hou, Jean
author_facet Andeen, Nicole K.
Abdulameer, Shahad
Charu, Vivek
Zuckerman, Jonathan E.
Troxell, Megan
Kambham, Neeraja
Alpers, Charles E.
Najafian, Behzad
Nicosia, Roberto F.
Smith, Kelly D.
Kung, Vanderlene L.
Avasare, Rupali S.
Vallurupalli, Anusha
Jefferson, J. Ashley
Hecox, Douglas
Swetnam, Leah
Yamashita, Michifumi
Lin, Mercury
Bissonnette, Mei Lin
Akilesh, Shreeram
Hou, Jean
author_sort Andeen, Nicole K.
collection PubMed
description INTRODUCTION: There are limited reports on kidney biopsy findings in patients with mantle cell lymphoma (MCL). METHODS: We initiated a multi-institutional, retrospective review of kidney biopsy findings in patients with active and treated MCL. RESULTS: A total of 30 patients with MCL and kidney biopsies were identified, with a median age of 67 (range 48–87) years, 73% of whom were men. A total of 20 patients had active MCL at the time of biopsy, of whom 14 (70%) presented with acute kidney injury (AKI), proteinuria and/or hematuria, and biopsy findings potentially attributable to lymphoma. Of the 14, 11 had immune complex (IC) or complement-mediated (C3) disease including proliferative glomerulonephritis (GN) with monotypic Ig deposits (PGNMID [2]), C3GN, (2), secondary membranous nephropathy (MN [3]), tubular basement membrane (TBM) deposits (2), and modest lupus-like GN (2). Lymphomatous infiltration was present in 8 of the 20 patients, 5 with coincident IC or C3 lesions. A total of 6 patients with available follow-up were treated for MCL, all with clinical remission of GN (2 PGNMID, 2 C3GN, and 2 MN). CONCLUSION: MCL is associated with diverse monoclonal and polyclonal glomerular and extra-glomerular IC and C3 disease. For patients with active MCL and kidney dysfunction requiring biopsy, 70% had findings due or potentially due to lymphoma, including 55% with IC or C3 disease and 40% had lymphomatous kidney infiltration. IC and C3GN in the setting of active MCL was responsive to lymphoma-directed therapy.
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spelling pubmed-88972912022-03-06 A Diverse Spectrum of Immune Complex– and Complement-Mediated Kidney Diseases Is Associated With Mantle Cell Lymphoma Andeen, Nicole K. Abdulameer, Shahad Charu, Vivek Zuckerman, Jonathan E. Troxell, Megan Kambham, Neeraja Alpers, Charles E. Najafian, Behzad Nicosia, Roberto F. Smith, Kelly D. Kung, Vanderlene L. Avasare, Rupali S. Vallurupalli, Anusha Jefferson, J. Ashley Hecox, Douglas Swetnam, Leah Yamashita, Michifumi Lin, Mercury Bissonnette, Mei Lin Akilesh, Shreeram Hou, Jean Kidney Int Rep Clinical Research INTRODUCTION: There are limited reports on kidney biopsy findings in patients with mantle cell lymphoma (MCL). METHODS: We initiated a multi-institutional, retrospective review of kidney biopsy findings in patients with active and treated MCL. RESULTS: A total of 30 patients with MCL and kidney biopsies were identified, with a median age of 67 (range 48–87) years, 73% of whom were men. A total of 20 patients had active MCL at the time of biopsy, of whom 14 (70%) presented with acute kidney injury (AKI), proteinuria and/or hematuria, and biopsy findings potentially attributable to lymphoma. Of the 14, 11 had immune complex (IC) or complement-mediated (C3) disease including proliferative glomerulonephritis (GN) with monotypic Ig deposits (PGNMID [2]), C3GN, (2), secondary membranous nephropathy (MN [3]), tubular basement membrane (TBM) deposits (2), and modest lupus-like GN (2). Lymphomatous infiltration was present in 8 of the 20 patients, 5 with coincident IC or C3 lesions. A total of 6 patients with available follow-up were treated for MCL, all with clinical remission of GN (2 PGNMID, 2 C3GN, and 2 MN). CONCLUSION: MCL is associated with diverse monoclonal and polyclonal glomerular and extra-glomerular IC and C3 disease. For patients with active MCL and kidney dysfunction requiring biopsy, 70% had findings due or potentially due to lymphoma, including 55% with IC or C3 disease and 40% had lymphomatous kidney infiltration. IC and C3GN in the setting of active MCL was responsive to lymphoma-directed therapy. Elsevier 2021-12-27 /pmc/articles/PMC8897291/ /pubmed/35257069 http://dx.doi.org/10.1016/j.ekir.2021.12.020 Text en © 2021 International Society of Nephrology. Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Clinical Research
Andeen, Nicole K.
Abdulameer, Shahad
Charu, Vivek
Zuckerman, Jonathan E.
Troxell, Megan
Kambham, Neeraja
Alpers, Charles E.
Najafian, Behzad
Nicosia, Roberto F.
Smith, Kelly D.
Kung, Vanderlene L.
Avasare, Rupali S.
Vallurupalli, Anusha
Jefferson, J. Ashley
Hecox, Douglas
Swetnam, Leah
Yamashita, Michifumi
Lin, Mercury
Bissonnette, Mei Lin
Akilesh, Shreeram
Hou, Jean
A Diverse Spectrum of Immune Complex– and Complement-Mediated Kidney Diseases Is Associated With Mantle Cell Lymphoma
title A Diverse Spectrum of Immune Complex– and Complement-Mediated Kidney Diseases Is Associated With Mantle Cell Lymphoma
title_full A Diverse Spectrum of Immune Complex– and Complement-Mediated Kidney Diseases Is Associated With Mantle Cell Lymphoma
title_fullStr A Diverse Spectrum of Immune Complex– and Complement-Mediated Kidney Diseases Is Associated With Mantle Cell Lymphoma
title_full_unstemmed A Diverse Spectrum of Immune Complex– and Complement-Mediated Kidney Diseases Is Associated With Mantle Cell Lymphoma
title_short A Diverse Spectrum of Immune Complex– and Complement-Mediated Kidney Diseases Is Associated With Mantle Cell Lymphoma
title_sort diverse spectrum of immune complex– and complement-mediated kidney diseases is associated with mantle cell lymphoma
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897291/
https://www.ncbi.nlm.nih.gov/pubmed/35257069
http://dx.doi.org/10.1016/j.ekir.2021.12.020
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