The sGC stimulator BAY-747 and activator runcaciguat can enhance memory in vivo via differential hippocampal plasticity mechanisms

Soluble guanylate cyclase (sGC) requires a heme-group bound in order to produce cGMP, a second messenger involved in memory formation, while heme-free sGC is inactive. Two compound classes can increase sGC activity: sGC stimulators acting on heme-bound sGC, and sGC activators acting on heme-free sGC...

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Detalles Bibliográficos
Autores principales: Nelissen, Ellis, Possemis, Nina, Van Goethem, Nick P., Schepers, Melissa, Mulder-Jongen, Danielle A. J., Dietz, Lisa, Janssen, Wiebke, Gerisch, Michael, Hüser, Jörg, Sandner, Peter, Vanmierlo, Tim, Prickaerts, Jos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897390/
https://www.ncbi.nlm.nih.gov/pubmed/35246566
http://dx.doi.org/10.1038/s41598-022-07391-1

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