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Expression of Neighbor of Punc E11 (NOPE) in early stage esophageal adenocarcinoma is associated with reduced survival

Current recommendations suggest neoadjuvant treatment in node-positive esophageal cancer or tumors staged T3 and upwards but some T2 N0 patients might benefit from neoadjuvant therapy. It is of clinical relevance to identify this subgroup. Loss of epithelial apicobasal polarity is a key factor in th...

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Autores principales: Kütting, Fabian, Gebauer, Florian, Zweerink, Susanne, Krämer, Laurenz, Schramm, Christoph, Quaas, Alexander, Bruns, Christiane, Goeser, Tobias, Nierhoff, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897453/
https://www.ncbi.nlm.nih.gov/pubmed/35246597
http://dx.doi.org/10.1038/s41598-022-07580-y
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author Kütting, Fabian
Gebauer, Florian
Zweerink, Susanne
Krämer, Laurenz
Schramm, Christoph
Quaas, Alexander
Bruns, Christiane
Goeser, Tobias
Nierhoff, Dirk
author_facet Kütting, Fabian
Gebauer, Florian
Zweerink, Susanne
Krämer, Laurenz
Schramm, Christoph
Quaas, Alexander
Bruns, Christiane
Goeser, Tobias
Nierhoff, Dirk
author_sort Kütting, Fabian
collection PubMed
description Current recommendations suggest neoadjuvant treatment in node-positive esophageal cancer or tumors staged T3 and upwards but some T2 N0 patients might benefit from neoadjuvant therapy. It is of clinical relevance to identify this subgroup. Loss of epithelial apicobasal polarity is a key factor in the development of invasive capabilities of carcinoma. The oncofetal stem/progenitor cell marker NOPE is expressed in adult depolarized murine hepatocytes and in murine/human hepatocellular carcinoma. We analyzed NOPE expression in 363 patients with esophageal adenocarcinoma using an RNA Scope Assay on a tissue microarray and correlated results with clinical data. Median follow-up was 57.7 months with a 5-year survival rate of 26.6%. NOPE was detectable in 32 patients (8.8%). In pT1/2 stages, NOPE expression was associated with a significantly reduced median OS of 6.3 months (95% CI 1.2–19.4 months), the median OS is not reached in the NOPE-negative group (calculated mean OS 117.1 months) (P = 0.012). In advanced tumor stages, a NOPE dependent survival difference was not detected. This is the first report of NOPE expression demonstrating a prognostic value in esophageal cancer. Early stage, NOPE positive patients are at a high risk of tumor progression and may benefit from neoadjuvant treatment analogous to advanced stage cancer.
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spelling pubmed-88974532022-03-08 Expression of Neighbor of Punc E11 (NOPE) in early stage esophageal adenocarcinoma is associated with reduced survival Kütting, Fabian Gebauer, Florian Zweerink, Susanne Krämer, Laurenz Schramm, Christoph Quaas, Alexander Bruns, Christiane Goeser, Tobias Nierhoff, Dirk Sci Rep Article Current recommendations suggest neoadjuvant treatment in node-positive esophageal cancer or tumors staged T3 and upwards but some T2 N0 patients might benefit from neoadjuvant therapy. It is of clinical relevance to identify this subgroup. Loss of epithelial apicobasal polarity is a key factor in the development of invasive capabilities of carcinoma. The oncofetal stem/progenitor cell marker NOPE is expressed in adult depolarized murine hepatocytes and in murine/human hepatocellular carcinoma. We analyzed NOPE expression in 363 patients with esophageal adenocarcinoma using an RNA Scope Assay on a tissue microarray and correlated results with clinical data. Median follow-up was 57.7 months with a 5-year survival rate of 26.6%. NOPE was detectable in 32 patients (8.8%). In pT1/2 stages, NOPE expression was associated with a significantly reduced median OS of 6.3 months (95% CI 1.2–19.4 months), the median OS is not reached in the NOPE-negative group (calculated mean OS 117.1 months) (P = 0.012). In advanced tumor stages, a NOPE dependent survival difference was not detected. This is the first report of NOPE expression demonstrating a prognostic value in esophageal cancer. Early stage, NOPE positive patients are at a high risk of tumor progression and may benefit from neoadjuvant treatment analogous to advanced stage cancer. Nature Publishing Group UK 2022-03-04 /pmc/articles/PMC8897453/ /pubmed/35246597 http://dx.doi.org/10.1038/s41598-022-07580-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Kütting, Fabian
Gebauer, Florian
Zweerink, Susanne
Krämer, Laurenz
Schramm, Christoph
Quaas, Alexander
Bruns, Christiane
Goeser, Tobias
Nierhoff, Dirk
Expression of Neighbor of Punc E11 (NOPE) in early stage esophageal adenocarcinoma is associated with reduced survival
title Expression of Neighbor of Punc E11 (NOPE) in early stage esophageal adenocarcinoma is associated with reduced survival
title_full Expression of Neighbor of Punc E11 (NOPE) in early stage esophageal adenocarcinoma is associated with reduced survival
title_fullStr Expression of Neighbor of Punc E11 (NOPE) in early stage esophageal adenocarcinoma is associated with reduced survival
title_full_unstemmed Expression of Neighbor of Punc E11 (NOPE) in early stage esophageal adenocarcinoma is associated with reduced survival
title_short Expression of Neighbor of Punc E11 (NOPE) in early stage esophageal adenocarcinoma is associated with reduced survival
title_sort expression of neighbor of punc e11 (nope) in early stage esophageal adenocarcinoma is associated with reduced survival
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897453/
https://www.ncbi.nlm.nih.gov/pubmed/35246597
http://dx.doi.org/10.1038/s41598-022-07580-y
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