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Experimental Search for New Means of Pathogenetic Therapy COVID-19: Inhibitor of H2-Receptors Famotidine Increases the Effect of Oseltamivir on Survival and Immune Status of Mice Infected by A/PR/8/34 (H1N1)

The development of drugs for the therapy of COVID-19 is one of the main problems of modern physiology, biochemistry and pharmacology. Taking into account the available information on the participation of mast cells and the role of histamine in the pathogenesis of COVID-19, as well as information on...

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Autores principales: Goncharov, N. V., Vasilyev, K. A., Kudryavtsev, I. V., Avdonin, P. P., Belinskaia, D. A., Stukova, M. A., Shamova, O. V., Avdonin, P. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pleiades Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897615/
https://www.ncbi.nlm.nih.gov/pubmed/35283537
http://dx.doi.org/10.1134/S0022093022010203
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author Goncharov, N. V.
Vasilyev, K. A.
Kudryavtsev, I. V.
Avdonin, P. P.
Belinskaia, D. A.
Stukova, M. A.
Shamova, O. V.
Avdonin, P. V.
author_facet Goncharov, N. V.
Vasilyev, K. A.
Kudryavtsev, I. V.
Avdonin, P. P.
Belinskaia, D. A.
Stukova, M. A.
Shamova, O. V.
Avdonin, P. V.
author_sort Goncharov, N. V.
collection PubMed
description The development of drugs for the therapy of COVID-19 is one of the main problems of modern physiology, biochemistry and pharmacology. Taking into account the available information on the participation of mast cells and the role of histamine in the pathogenesis of COVID-19, as well as information on the positive role of famotidine in the prevention and treatment of coronavirus infection, an experiment was carried out using famotidine in a mouse model. We used a type A/PR/8/34 (H1N1) virus adapted to mice. The antiviral drug oseltamivir (Tamiflu), which belongs to the group of neuraminidase inhibitors, was used as a reference drug. The use of famotidine in combination with oseltamivir can increase survival, improve the dynamics of animal weight, reduce the level of NKT cells and increase the level of naive T-helpers. Further studies of famotidine in vivo should be aimed at optimizing the regimen of drug use at a higher viral load, as well as with a longer use of famotidine.
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spelling pubmed-88976152022-03-07 Experimental Search for New Means of Pathogenetic Therapy COVID-19: Inhibitor of H2-Receptors Famotidine Increases the Effect of Oseltamivir on Survival and Immune Status of Mice Infected by A/PR/8/34 (H1N1) Goncharov, N. V. Vasilyev, K. A. Kudryavtsev, I. V. Avdonin, P. P. Belinskaia, D. A. Stukova, M. A. Shamova, O. V. Avdonin, P. V. J Evol Biochem Physiol Experimental Papers The development of drugs for the therapy of COVID-19 is one of the main problems of modern physiology, biochemistry and pharmacology. Taking into account the available information on the participation of mast cells and the role of histamine in the pathogenesis of COVID-19, as well as information on the positive role of famotidine in the prevention and treatment of coronavirus infection, an experiment was carried out using famotidine in a mouse model. We used a type A/PR/8/34 (H1N1) virus adapted to mice. The antiviral drug oseltamivir (Tamiflu), which belongs to the group of neuraminidase inhibitors, was used as a reference drug. The use of famotidine in combination with oseltamivir can increase survival, improve the dynamics of animal weight, reduce the level of NKT cells and increase the level of naive T-helpers. Further studies of famotidine in vivo should be aimed at optimizing the regimen of drug use at a higher viral load, as well as with a longer use of famotidine. Pleiades Publishing 2022-03-05 2022 /pmc/articles/PMC8897615/ /pubmed/35283537 http://dx.doi.org/10.1134/S0022093022010203 Text en © Pleiades Publishing, Ltd. 2022, corrected publication 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Experimental Papers
Goncharov, N. V.
Vasilyev, K. A.
Kudryavtsev, I. V.
Avdonin, P. P.
Belinskaia, D. A.
Stukova, M. A.
Shamova, O. V.
Avdonin, P. V.
Experimental Search for New Means of Pathogenetic Therapy COVID-19: Inhibitor of H2-Receptors Famotidine Increases the Effect of Oseltamivir on Survival and Immune Status of Mice Infected by A/PR/8/34 (H1N1)
title Experimental Search for New Means of Pathogenetic Therapy COVID-19: Inhibitor of H2-Receptors Famotidine Increases the Effect of Oseltamivir on Survival and Immune Status of Mice Infected by A/PR/8/34 (H1N1)
title_full Experimental Search for New Means of Pathogenetic Therapy COVID-19: Inhibitor of H2-Receptors Famotidine Increases the Effect of Oseltamivir on Survival and Immune Status of Mice Infected by A/PR/8/34 (H1N1)
title_fullStr Experimental Search for New Means of Pathogenetic Therapy COVID-19: Inhibitor of H2-Receptors Famotidine Increases the Effect of Oseltamivir on Survival and Immune Status of Mice Infected by A/PR/8/34 (H1N1)
title_full_unstemmed Experimental Search for New Means of Pathogenetic Therapy COVID-19: Inhibitor of H2-Receptors Famotidine Increases the Effect of Oseltamivir on Survival and Immune Status of Mice Infected by A/PR/8/34 (H1N1)
title_short Experimental Search for New Means of Pathogenetic Therapy COVID-19: Inhibitor of H2-Receptors Famotidine Increases the Effect of Oseltamivir on Survival and Immune Status of Mice Infected by A/PR/8/34 (H1N1)
title_sort experimental search for new means of pathogenetic therapy covid-19: inhibitor of h2-receptors famotidine increases the effect of oseltamivir on survival and immune status of mice infected by a/pr/8/34 (h1n1)
topic Experimental Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897615/
https://www.ncbi.nlm.nih.gov/pubmed/35283537
http://dx.doi.org/10.1134/S0022093022010203
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