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Experimental Search for New Means of Pathogenetic Therapy COVID-19: Inhibitor of H2-Receptors Famotidine Increases the Effect of Oseltamivir on Survival and Immune Status of Mice Infected by A/PR/8/34 (H1N1)
The development of drugs for the therapy of COVID-19 is one of the main problems of modern physiology, biochemistry and pharmacology. Taking into account the available information on the participation of mast cells and the role of histamine in the pathogenesis of COVID-19, as well as information on...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Pleiades Publishing
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897615/ https://www.ncbi.nlm.nih.gov/pubmed/35283537 http://dx.doi.org/10.1134/S0022093022010203 |
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author | Goncharov, N. V. Vasilyev, K. A. Kudryavtsev, I. V. Avdonin, P. P. Belinskaia, D. A. Stukova, M. A. Shamova, O. V. Avdonin, P. V. |
author_facet | Goncharov, N. V. Vasilyev, K. A. Kudryavtsev, I. V. Avdonin, P. P. Belinskaia, D. A. Stukova, M. A. Shamova, O. V. Avdonin, P. V. |
author_sort | Goncharov, N. V. |
collection | PubMed |
description | The development of drugs for the therapy of COVID-19 is one of the main problems of modern physiology, biochemistry and pharmacology. Taking into account the available information on the participation of mast cells and the role of histamine in the pathogenesis of COVID-19, as well as information on the positive role of famotidine in the prevention and treatment of coronavirus infection, an experiment was carried out using famotidine in a mouse model. We used a type A/PR/8/34 (H1N1) virus adapted to mice. The antiviral drug oseltamivir (Tamiflu), which belongs to the group of neuraminidase inhibitors, was used as a reference drug. The use of famotidine in combination with oseltamivir can increase survival, improve the dynamics of animal weight, reduce the level of NKT cells and increase the level of naive T-helpers. Further studies of famotidine in vivo should be aimed at optimizing the regimen of drug use at a higher viral load, as well as with a longer use of famotidine. |
format | Online Article Text |
id | pubmed-8897615 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Pleiades Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-88976152022-03-07 Experimental Search for New Means of Pathogenetic Therapy COVID-19: Inhibitor of H2-Receptors Famotidine Increases the Effect of Oseltamivir on Survival and Immune Status of Mice Infected by A/PR/8/34 (H1N1) Goncharov, N. V. Vasilyev, K. A. Kudryavtsev, I. V. Avdonin, P. P. Belinskaia, D. A. Stukova, M. A. Shamova, O. V. Avdonin, P. V. J Evol Biochem Physiol Experimental Papers The development of drugs for the therapy of COVID-19 is one of the main problems of modern physiology, biochemistry and pharmacology. Taking into account the available information on the participation of mast cells and the role of histamine in the pathogenesis of COVID-19, as well as information on the positive role of famotidine in the prevention and treatment of coronavirus infection, an experiment was carried out using famotidine in a mouse model. We used a type A/PR/8/34 (H1N1) virus adapted to mice. The antiviral drug oseltamivir (Tamiflu), which belongs to the group of neuraminidase inhibitors, was used as a reference drug. The use of famotidine in combination with oseltamivir can increase survival, improve the dynamics of animal weight, reduce the level of NKT cells and increase the level of naive T-helpers. Further studies of famotidine in vivo should be aimed at optimizing the regimen of drug use at a higher viral load, as well as with a longer use of famotidine. Pleiades Publishing 2022-03-05 2022 /pmc/articles/PMC8897615/ /pubmed/35283537 http://dx.doi.org/10.1134/S0022093022010203 Text en © Pleiades Publishing, Ltd. 2022, corrected publication 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Experimental Papers Goncharov, N. V. Vasilyev, K. A. Kudryavtsev, I. V. Avdonin, P. P. Belinskaia, D. A. Stukova, M. A. Shamova, O. V. Avdonin, P. V. Experimental Search for New Means of Pathogenetic Therapy COVID-19: Inhibitor of H2-Receptors Famotidine Increases the Effect of Oseltamivir on Survival and Immune Status of Mice Infected by A/PR/8/34 (H1N1) |
title | Experimental Search for New Means of Pathogenetic Therapy COVID-19: Inhibitor of H2-Receptors Famotidine Increases the Effect of Oseltamivir on Survival and Immune Status of Mice Infected by A/PR/8/34 (H1N1) |
title_full | Experimental Search for New Means of Pathogenetic Therapy COVID-19: Inhibitor of H2-Receptors Famotidine Increases the Effect of Oseltamivir on Survival and Immune Status of Mice Infected by A/PR/8/34 (H1N1) |
title_fullStr | Experimental Search for New Means of Pathogenetic Therapy COVID-19: Inhibitor of H2-Receptors Famotidine Increases the Effect of Oseltamivir on Survival and Immune Status of Mice Infected by A/PR/8/34 (H1N1) |
title_full_unstemmed | Experimental Search for New Means of Pathogenetic Therapy COVID-19: Inhibitor of H2-Receptors Famotidine Increases the Effect of Oseltamivir on Survival and Immune Status of Mice Infected by A/PR/8/34 (H1N1) |
title_short | Experimental Search for New Means of Pathogenetic Therapy COVID-19: Inhibitor of H2-Receptors Famotidine Increases the Effect of Oseltamivir on Survival and Immune Status of Mice Infected by A/PR/8/34 (H1N1) |
title_sort | experimental search for new means of pathogenetic therapy covid-19: inhibitor of h2-receptors famotidine increases the effect of oseltamivir on survival and immune status of mice infected by a/pr/8/34 (h1n1) |
topic | Experimental Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897615/ https://www.ncbi.nlm.nih.gov/pubmed/35283537 http://dx.doi.org/10.1134/S0022093022010203 |
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