Expression of gamma-glutamyltransferase 1 in glioblastoma cells confers resistance to cystine deprivation–induced ferroptosis

Ferroptosis is an iron-dependent mode of cell death caused by excessive oxidative damage to lipids. Lipid peroxidation is normally suppressed by glutathione peroxidase 4, which requires reduced glutathione. Cystine is a major resource for glutathione synthesis, especially in cancer cells. Therefore,...

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Detalles Bibliográficos
Autores principales: Hayashima, Kazuki, Katoh, Hironori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897698/
https://www.ncbi.nlm.nih.gov/pubmed/35148992
http://dx.doi.org/10.1016/j.jbc.2022.101703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897698/
https://www.ncbi.nlm.nih.gov/pubmed/35148992
http://dx.doi.org/10.1016/j.jbc.2022.101703

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