Clinically relevant T cell expansion media activate distinct metabolic programs uncoupled from cellular function

Ex vivo expansion conditions used to generate T cells for immunotherapy are thought to adopt metabolic phenotypes that impede therapeutic efficacy in vivo. The comparison of five different culture media used for clinical T cell expansion revealed unique optima based on different output variables, in...

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Detalles Bibliográficos
Autores principales: MacPherson, Sarah, Keyes, Sarah, Kilgour, Marisa K., Smazynski, Julian, Chan, Vanessa, Sudderth, Jessica, Turcotte, Tim, Devlieger, Adria, Yu, Jessie, Huggler, Kimberly S., Cantor, Jason R., DeBerardinis, Ralph J., Siatskas, Christopher, Lum, Julian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897702/
https://www.ncbi.nlm.nih.gov/pubmed/35284590
http://dx.doi.org/10.1016/j.omtm.2022.02.004

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