The importance of miRNA-630 in human diseases with an especial focus on cancers

miR-630 is encoded by MIR630 gene (NC_000015.10) on 15q24.1. This miRNA is mostly associated with cytokine signaling in immune system. Several neoplastic as well as non-neoplastic conditions have been linked with dysregulation of miR-630. It is an oncogenic miRNA in renal cell carcinoma, multiple my...

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Autores principales: Kadkhoda, Sepideh, Ghafouri-Fard, Soudeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897855/
https://www.ncbi.nlm.nih.gov/pubmed/35248081
http://dx.doi.org/10.1186/s12935-022-02531-z
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author Kadkhoda, Sepideh
Ghafouri-Fard, Soudeh
author_facet Kadkhoda, Sepideh
Ghafouri-Fard, Soudeh
author_sort Kadkhoda, Sepideh
collection PubMed
description miR-630 is encoded by MIR630 gene (NC_000015.10) on 15q24.1. This miRNA is mostly associated with cytokine signaling in immune system. Several neoplastic as well as non-neoplastic conditions have been linked with dysregulation of miR-630. It is an oncogenic miRNA in renal cell carcinoma, multiple myeloma, colorectal cancer, acute lymphoblastic leukemia, ovarian cancer and prostate cancer. On the other hand, it is a putative tumor suppressor miRNA in lung, cervical, breast, thyroid and esophageal tissues. In a number of other tissues, data regarding the role of miR-630 in the carcinogenesis is conflicting. Expression levels of miR-630 can be used as markers for prediction of cancer course. Moreover, miR-630 can influence response to chemoradiotherapy. This miRNA is also involved in the pathoetiology of IgA nephropathy, obstructive sleep apnea, age-related nuclear cataract and vitiligo. In the present review, we discuss the role of miR-630 in these conditions.
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spelling pubmed-88978552022-03-14 The importance of miRNA-630 in human diseases with an especial focus on cancers Kadkhoda, Sepideh Ghafouri-Fard, Soudeh Cancer Cell Int Review miR-630 is encoded by MIR630 gene (NC_000015.10) on 15q24.1. This miRNA is mostly associated with cytokine signaling in immune system. Several neoplastic as well as non-neoplastic conditions have been linked with dysregulation of miR-630. It is an oncogenic miRNA in renal cell carcinoma, multiple myeloma, colorectal cancer, acute lymphoblastic leukemia, ovarian cancer and prostate cancer. On the other hand, it is a putative tumor suppressor miRNA in lung, cervical, breast, thyroid and esophageal tissues. In a number of other tissues, data regarding the role of miR-630 in the carcinogenesis is conflicting. Expression levels of miR-630 can be used as markers for prediction of cancer course. Moreover, miR-630 can influence response to chemoradiotherapy. This miRNA is also involved in the pathoetiology of IgA nephropathy, obstructive sleep apnea, age-related nuclear cataract and vitiligo. In the present review, we discuss the role of miR-630 in these conditions. BioMed Central 2022-03-05 /pmc/articles/PMC8897855/ /pubmed/35248081 http://dx.doi.org/10.1186/s12935-022-02531-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Kadkhoda, Sepideh
Ghafouri-Fard, Soudeh
The importance of miRNA-630 in human diseases with an especial focus on cancers
title The importance of miRNA-630 in human diseases with an especial focus on cancers
title_full The importance of miRNA-630 in human diseases with an especial focus on cancers
title_fullStr The importance of miRNA-630 in human diseases with an especial focus on cancers
title_full_unstemmed The importance of miRNA-630 in human diseases with an especial focus on cancers
title_short The importance of miRNA-630 in human diseases with an especial focus on cancers
title_sort importance of mirna-630 in human diseases with an especial focus on cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897855/
https://www.ncbi.nlm.nih.gov/pubmed/35248081
http://dx.doi.org/10.1186/s12935-022-02531-z
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