Cargando…

Prevalence of human papilloma virus (HPV) genotypes between outpatients males and females referred to seven laboratories in Tehran, Iran

BACKGROUND: Human papilloma virus (HPV) causes the most common sexually-transmitted infection especially among sexually-active individuals. The aim of study was to characterize the molecular characterization of HPV genotypes between 5176 female and male patients. METHODS: HPV DNA was extracted from...

Descripción completa

Detalles Bibliográficos
Autores principales: Rezaee Azhar, Iman, Yaghoobi, Mahmood, Mossalaeie, Mir Majid, Kollaee Darabi, Abolghasem, Nejadeh, Amir Houshang, Jamshidi, Mahbobeh, Ahani, Ali, Karkhane Mahmoodi, Masoud, Ghalichi, Leila, Shabanzadeh, Ayda, Ataei-Pirkooh, Angila, Marjani, Arezoo, Khamseh, Azam, Shafiei, Motahareh, Hosseini, Parastoo, Soltani, Saber, Zandi, Milad, Ghafari, Parsa, Aboofazeli, Amir, Ghaziasadi, Azam, Jazayeri, Seyed Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897875/
https://www.ncbi.nlm.nih.gov/pubmed/35248145
http://dx.doi.org/10.1186/s13027-022-00421-7
Descripción
Sumario:BACKGROUND: Human papilloma virus (HPV) causes the most common sexually-transmitted infection especially among sexually-active individuals. The aim of study was to characterize the molecular characterization of HPV genotypes between 5176 female and male patients. METHODS: HPV DNA was extracted from genital swabs of the study participants and amplified by Real Time Polymerase Chain Reaction (PCR). Genotyping was performed for 2525 cases using REALQUALITY RQ-Multi HPV Detection Kit for the identification of 14 high risk (HR) and 2 low risk (LR) HPV genotypes. Demographic figures were analyzed in correlation with virological data statistically. RESULTS: Out of 5176 cases from 7 laboratories, 2727 (53%) were positive for HPV, of which. 2372(87%) women and 355 (13%) men were HPV positive. However, in an intra-gender analysis, positive rate was higher in men (355/637, 55.7%) than in women (2372/4539, 52%; P value 0.007). HPV positive patients were younger than negative individuals. Positive rate was higher among age categories 20–40. Genotyping was performed for 2525 cases. Out of 1219 (48%) patients who contained single genotypes, 566 (22%) and 653 (26%) harboured HR and LR genotypes, respectively. In females and males, 1189 (54%) and 117 (37%) contained multiple genotypes. No substantial associations were found between different age categories and HR/LR and multiple genotypes distribution. CONCLUSION: The prevalence of HPV infection in both genders was high. However, men had a higher rate of infection. These observations highlighted the necessity for a plan for targeted education to younger population in the society as well as application of infection control measures against HPV infection, especially in terms of general population mass HPV vaccination.