Cyclical regression covariates remove the major confounding effect of cyclical developmental gene expression with strain-specific drug response in the malaria parasite Plasmodium falciparum

BACKGROUND: The cyclical nature of gene expression in the intraerythrocytic development cycle (IDC) of the malaria parasite, Plasmodium falciparum, confounds the accurate detection of specific transcriptional differences, e.g. as provoked by the development of drug resistance. In lab-based studies,...

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Detalles Bibliográficos
Autores principales: Foster, Gabriel J., Sievert, Mackenzie A. C., Button-Simons, Katrina, Vendrely, Katelyn M., Romero-Severson, Jeanne, Ferdig, Michael T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897900/
https://www.ncbi.nlm.nih.gov/pubmed/35247977
http://dx.doi.org/10.1186/s12864-021-08281-y

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