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Epidemiology of familial multiple sclerosis in Iran: a national registry-based study

BACKGROUND: Admittedly, little is known about the epidemiological signatures of familial multiple sclerosis (FMS) in different geographical regions of Iran. OBJECTIVE: To determine the epidemiology and the risk of FMS incidence in several provinces of Iran with a different ethnic population includin...

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Autores principales: Salehi, Zahra, Almasi-Hashiani, Amir, Sahraian, Mohammad Ali, Ashtari, Fereshteh, Baghbanian, Seyed Mohammad, Razazian, Nazanin, Moghadasi, Abdorreza Naser, Bayati, Asghar, Azimi, Amir Reza, Beladimoghadam, Nahid, Harirchian, Mohammad Hossein, Poursadeghfard, Maryam, Navardi, Samira, Shirkoohi, Reza, Heidari, Hora, Ghaffari, Mehran, Eskandarieh, Sharareh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897924/
https://www.ncbi.nlm.nih.gov/pubmed/35248009
http://dx.doi.org/10.1186/s12883-022-02609-1
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author Salehi, Zahra
Almasi-Hashiani, Amir
Sahraian, Mohammad Ali
Ashtari, Fereshteh
Baghbanian, Seyed Mohammad
Razazian, Nazanin
Moghadasi, Abdorreza Naser
Bayati, Asghar
Azimi, Amir Reza
Beladimoghadam, Nahid
Harirchian, Mohammad Hossein
Poursadeghfard, Maryam
Navardi, Samira
Shirkoohi, Reza
Heidari, Hora
Ghaffari, Mehran
Eskandarieh, Sharareh
author_facet Salehi, Zahra
Almasi-Hashiani, Amir
Sahraian, Mohammad Ali
Ashtari, Fereshteh
Baghbanian, Seyed Mohammad
Razazian, Nazanin
Moghadasi, Abdorreza Naser
Bayati, Asghar
Azimi, Amir Reza
Beladimoghadam, Nahid
Harirchian, Mohammad Hossein
Poursadeghfard, Maryam
Navardi, Samira
Shirkoohi, Reza
Heidari, Hora
Ghaffari, Mehran
Eskandarieh, Sharareh
author_sort Salehi, Zahra
collection PubMed
description BACKGROUND: Admittedly, little is known about the epidemiological signatures of familial multiple sclerosis (FMS) in different geographical regions of Iran. OBJECTIVE: To determine the epidemiology and the risk of FMS incidence in several provinces of Iran with a different ethnic population including, Fars, Tehran, Isfahan (Persians), and Mazandaran (Mazanis), Kermanshah (Kurds), and Chaharmahal and Bakhtiari (Lors). METHODS: This cross-sectional registry-based study was performed on nationwide MS registry of Iran (NMSRI) data collected from 2018 to 2021. This system, registers baseline characteristics, clinical presentations and symptoms, diagnostic and treatments at regional and national levels. RESULTS: A total of 9200 patients including, 7003 (76.1%) female and 2197 (23.9%) male, were participated. About 19% of patients reported a family history of MS; the order from highest to lowest FMS prevalence was as follows: Fars (26.5%), Chaharmahal and Bakhtiari (21.1%), Tehran (20.5%), Isfahan (20.3%), Mazandaran (18.0%), and Kermanshah (12.5%). Of all FMS cases, 74.7% (1308 cases) were female and 25.3% (442 cases) were male. FMS occurrence was much more common in females than males (P-value = 0.001). Further, the mean age at onset was 30 years among FMS cases. A substantially higher probability of relapsing-remitting MS and secondary-progressive MS was found among FMS cases than sporadic MS (SMS) (P_value = 0.001). There was no significant difference in Expanded Disability Status Scale (EDSS) scores between FMS and SMS. The majority of FMS cases were observed among first-degree relatives, with the highest rate in siblings. There was a significant association between MS risk and positive familial history in both maternal and paternal aunt/uncle (P_value = 0.043 and P_value = 0.019, respectively). Multiple sclerosis occurrence among offspring of females was higher than males (P_value = 0.027). CONCLUSIONS: In summary, our findings imply a noteworthy upward trend of FMS in Iran, even more than the global prevalence, which suggests a unique Atlas of FMS prevalence in this multi-ethnic population. Despite the highest rate of FMS within Persian and Lor ethnicities, no statistically significant difference was observed among the provinces.
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spelling pubmed-88979242022-03-16 Epidemiology of familial multiple sclerosis in Iran: a national registry-based study Salehi, Zahra Almasi-Hashiani, Amir Sahraian, Mohammad Ali Ashtari, Fereshteh Baghbanian, Seyed Mohammad Razazian, Nazanin Moghadasi, Abdorreza Naser Bayati, Asghar Azimi, Amir Reza Beladimoghadam, Nahid Harirchian, Mohammad Hossein Poursadeghfard, Maryam Navardi, Samira Shirkoohi, Reza Heidari, Hora Ghaffari, Mehran Eskandarieh, Sharareh BMC Neurol Research BACKGROUND: Admittedly, little is known about the epidemiological signatures of familial multiple sclerosis (FMS) in different geographical regions of Iran. OBJECTIVE: To determine the epidemiology and the risk of FMS incidence in several provinces of Iran with a different ethnic population including, Fars, Tehran, Isfahan (Persians), and Mazandaran (Mazanis), Kermanshah (Kurds), and Chaharmahal and Bakhtiari (Lors). METHODS: This cross-sectional registry-based study was performed on nationwide MS registry of Iran (NMSRI) data collected from 2018 to 2021. This system, registers baseline characteristics, clinical presentations and symptoms, diagnostic and treatments at regional and national levels. RESULTS: A total of 9200 patients including, 7003 (76.1%) female and 2197 (23.9%) male, were participated. About 19% of patients reported a family history of MS; the order from highest to lowest FMS prevalence was as follows: Fars (26.5%), Chaharmahal and Bakhtiari (21.1%), Tehran (20.5%), Isfahan (20.3%), Mazandaran (18.0%), and Kermanshah (12.5%). Of all FMS cases, 74.7% (1308 cases) were female and 25.3% (442 cases) were male. FMS occurrence was much more common in females than males (P-value = 0.001). Further, the mean age at onset was 30 years among FMS cases. A substantially higher probability of relapsing-remitting MS and secondary-progressive MS was found among FMS cases than sporadic MS (SMS) (P_value = 0.001). There was no significant difference in Expanded Disability Status Scale (EDSS) scores between FMS and SMS. The majority of FMS cases were observed among first-degree relatives, with the highest rate in siblings. There was a significant association between MS risk and positive familial history in both maternal and paternal aunt/uncle (P_value = 0.043 and P_value = 0.019, respectively). Multiple sclerosis occurrence among offspring of females was higher than males (P_value = 0.027). CONCLUSIONS: In summary, our findings imply a noteworthy upward trend of FMS in Iran, even more than the global prevalence, which suggests a unique Atlas of FMS prevalence in this multi-ethnic population. Despite the highest rate of FMS within Persian and Lor ethnicities, no statistically significant difference was observed among the provinces. BioMed Central 2022-03-05 /pmc/articles/PMC8897924/ /pubmed/35248009 http://dx.doi.org/10.1186/s12883-022-02609-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Salehi, Zahra
Almasi-Hashiani, Amir
Sahraian, Mohammad Ali
Ashtari, Fereshteh
Baghbanian, Seyed Mohammad
Razazian, Nazanin
Moghadasi, Abdorreza Naser
Bayati, Asghar
Azimi, Amir Reza
Beladimoghadam, Nahid
Harirchian, Mohammad Hossein
Poursadeghfard, Maryam
Navardi, Samira
Shirkoohi, Reza
Heidari, Hora
Ghaffari, Mehran
Eskandarieh, Sharareh
Epidemiology of familial multiple sclerosis in Iran: a national registry-based study
title Epidemiology of familial multiple sclerosis in Iran: a national registry-based study
title_full Epidemiology of familial multiple sclerosis in Iran: a national registry-based study
title_fullStr Epidemiology of familial multiple sclerosis in Iran: a national registry-based study
title_full_unstemmed Epidemiology of familial multiple sclerosis in Iran: a national registry-based study
title_short Epidemiology of familial multiple sclerosis in Iran: a national registry-based study
title_sort epidemiology of familial multiple sclerosis in iran: a national registry-based study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897924/
https://www.ncbi.nlm.nih.gov/pubmed/35248009
http://dx.doi.org/10.1186/s12883-022-02609-1
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