Clofazimine derivatives as potent broad-spectrum antiviral agents with dual-target mechanism

Thirty-two clofazimine derivatives, of which twenty-two were new, were synthesized and evaluated for their antiviral effects against both rabies virus and pseudo-typed SARS-CoV-2, taking clofazimine (1) as the lead. Among them, compound 15f bearing 4-methoxy-2-pyridyl at the N5-position showed super...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Xintong, Shi, Yulong, Guo, Zhihao, Zhao, Xiaoqiang, Wu, Jiajing, Cao, Shouchun, Liu, Yonghua, Li, Yuhua, Huang, Weijin, Wang, Youchun, Liu, Qiang, Li, Yinghong, Song, Danqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Masson SAS. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897968/
https://www.ncbi.nlm.nih.gov/pubmed/35279610
http://dx.doi.org/10.1016/j.ejmech.2022.114209

Ejemplares similares

Ejemplares similares