Cargando…

MiR-1301-3p Inhibits Epithelial-Mesenchymal Transition via Targeting RhoA in Pancreatic Cancer

Micro(mi)RNAs play an essential role in the epithelial-mesenchymal transition (EMT) process in human cancers. This study aimed to uncover the regulatory mechanism of miR-1301-3p on EMT in pancreatic cancer (PC). The miRNA profilings from Gene Expression Omnibus data sets (GSE31568, GSE41372, and GSE...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Xinxue, Ren, Zhangyong, Xu, Junming, Chen, Qing, Ma, Jun, Liu, Zhe, Kou, Jiantao, Zhao, Xin, Lang, Ren, He, Qiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8898114/ https://www.ncbi.nlm.nih.gov/pubmed/35256884 http://dx.doi.org/10.1155/2022/5514715

Ejemplares similares

RhoA/Rho-kinase triggers epithelial-mesenchymal transition in mesothelial cells and contributes to the pathogenesis of dialysis-related peritoneal fibrosis
por: Wang, Qinglian, et al.
Publicado: (2018)

RhoA/ROCK pathway mediates the effect of oestrogen on regulating epithelial‐mesenchymal transition and proliferation in endometriosis
por: Huang, Zhi‐Xiong, et al.
Publicado: (2020)

Modulating RhoA effectors induces transitions to oscillatory and more wavelike RhoA dynamics in Caenorhabditis elegans zygotes
por: Yao, Baixue, et al.
Publicado: (2022)

MicroRNA-122 Triggers Mesenchymal-Epithelial Transition and Suppresses Hepatocellular Carcinoma Cell Motility and Invasion by Targeting RhoA
por: Wang, Sheng-Chun, et al.
Publicado: (2014)

Single-cell transcriptomics reveals heterogeneous progression and EGFR activation in pancreatic adenosquamous carcinoma
por: Zhao, Xin, et al.
Publicado: (2021)

Simvastatin alleviates epithelial-mesenchymal transition and oxidative stress of high glucose-induced lens epithelial cells in vitro by inhibiting RhoA/ROCK signaling
por: Fu, Jianming, et al.
Publicado: (2022)

RhoA-Dependent HGF and c-Met Mediate Gas6-Induced Inhibition of Epithelial–Mesenchymal Transition, Migration, and Invasion of Lung Alveolar Epithelial Cells
por: Jung, Jihye, et al.
Publicado: (2019)

Aberrant Expression of miR-1301 in Human Cancer
por: Zhong, Chenming, et al.
Publicado: (2022)

Histamine-induced biphasic activation of RhoA allows for persistent RhoA signaling
por: Zhang, Jason Z., et al.
Publicado: (2020)

IBP regulates epithelial-to-mesenchymal transition and the motility of breast cancer cells via Rac1, RhoA and Cdc42 signaling pathways
por: Zhang, Z, et al.
Publicado: (2014)

Supervillin promotes epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma in hypoxia via activation of the RhoA/ROCK-ERK/p38 pathway
por: Chen, Xueran, et al.
Publicado: (2018)

RhoA improves cryopreservation of rooster sperm through the Rho/RhoA-associated kinase/cofilin pathway
por: Heng, Nuo, et al.
Publicado: (2022)

RhoA of the Rho Family Small GTPases Is Essential for B Lymphocyte Development
por: Zhang, Shuangmin, et al.
Publicado: (2012)

RhoA GTPase inhibition organizes contraction during epithelial morphogenesis
por: Mason, Frank M., et al.
Publicado: (2016)

HUNK inhibits epithelial-mesenchymal transition of CRC via direct phosphorylation of GEF-H1 and activating RhoA/LIMK-1/CFL-1
por: Han, Xiaoqi, et al.
Publicado: (2023)

MgcRacGAP restricts active RhoA at the cytokinetic furrow and both RhoA and Rac1 at cell–cell junctions in epithelial cells
por: Breznau, Elaina B., et al.
Publicado: (2015)

RhoA/Rho kinase in spinal cord injury
por: Wu, Xiangbing, et al.
Publicado: (2016)

Integrin-β4 regulates the dynamic changes of phenotypic characteristics in association with epithelial-mesenchymal transition (EMT) and RhoA activity in airway epithelial cells during injury and repair
por: Tan, Mei-Ling, et al.
Publicado: (2022)

High RhoA activity maintains the undifferentiated mesenchymal cell phenotype, whereas RhoA down-regulation by laminin-2 induces smooth muscle myogenesis
por: Beqaj, Safedin, et al.
Publicado: (2002)

RhoA controls furrow formation
por: Tuma, Rabiya S.
Publicado: (2005)

RhoA brings up the rear
por: Dove, Alan W.
Publicado: (2001)

Complementary receptors control RhoA
por: Robinson, Richard
Publicado: (2008)

RhoA Regulation of Cardiomyocyte Differentiation
por: Kaarbø, Mari, et al.
Publicado: (2013)

RhoA in aneurysmal subarachnoid hemorrhage
por: Ureña, Juan, et al.
Publicado: (2019)

RhoA Signaling in Neurodegenerative Diseases
por: Schmidt, Sissel Ida, et al.
Publicado: (2022)

The role of RhoA/Rho kinase pathway in endothelial dysfunction
por: Yao, Lin, et al.
Publicado: (2010)

Afadin and RhoA control pancreatic endocrine mass via lumen morphogenesis
por: Azizoglu, D. Berfin, et al.
Publicado: (2017)

RhoA phosphorylation mediated by Rho/RhoA-associated kinase pathway improves the anti-freezing potentiality of murine hatched and diapaused blastocysts
por: Gu, Meichao, et al.
Publicado: (2017)

The three-way switch operation of Rac1/RhoA GTPase-based circuit controlling amoeboid-hybrid-mesenchymal transition
por: Huang, Bin, et al.
Publicado: (2014)

A TRANSCRIPTIONAL CROSS–TALK BETWEEN RhoA AND c–Myc INHIBITS THE RhoA/Rock–DEPENDENT CYTOSKELETON
por: Sauzeau, Vincent, et al.
Publicado: (2010)

Arp2/3-Branched Actin Maintains an Active Pool of GTP-RhoA and Controls RhoA Abundance
por: Huang, Yuxing, et al.
Publicado: (2019)

RhoA, RhoB and RhoC differentially regulate endothelial barrier function
por: Pronk, Manon C. A., et al.
Publicado: (2017)

Spatially restricted activation of RhoA at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis
por: Terry, Stephen J., et al.
Publicado: (2011)

Loss of the obscurin-RhoGEF downregulates RhoA signaling and increases microtentacle formation and attachment of breast epithelial cells
por: Perry, Nicole A., et al.
Publicado: (2014)

The role of RhoC in epithelial-to-mesenchymal transition of ovarian carcinoma cells
por: Gou, Wen-feng, et al.
Publicado: (2014)

The Involvement of RhoA and Wnt-5a in the Tumorigenesis and Progression of Ovarian Epithelial Carcinoma
por: Chen, Shuo, et al.
Publicado: (2013)

EpCAM promotes endosomal modulation of the cortical RhoA zone for epithelial organization
por: Gaston, Cécile, et al.
Publicado: (2021)

RhoA/Rho‐kinases in asthma: from pathogenesis to therapeutic targets
por: Zhang, Yan, et al.
Publicado: (2020)

miR-31 controls osteoclast formation and bone resorption by targeting RhoA
por: Mizoguchi, Fumitaka, et al.
Publicado: (2013)

Crystal structures of the PH domains from Lbc family of RhoGEFs bound to activated RhoA GTPase
por: Chen, Zhe, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_sv3q8sr3aqp6hc10fnt50i5ef7