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PBRM1 Inactivation Promotes Upregulation of Human Endogenous Retroviruses in a HIF-Dependent Manner

Clear cell renal cell carcinoma (ccRCC) is considered an immunotherapy-responsive disease; however, the reasons for this remain unclear. Studies have variably implicated PBRM1 mutations as a predictive biomarker of immune checkpoint blockade (ICB) response, and separate studies demonstrate that expr...

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Detalles Bibliográficos
Autores principales:	Zhou, Mi, Leung, Janet Y., Gessner, Kathryn H., Hepperla, Austin J., Simon, Jeremy M., Davis, Ian J., Kim, William Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2022
Materias:	Priority Brief
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8898299/ https://www.ncbi.nlm.nih.gov/pubmed/35013001 http://dx.doi.org/10.1158/2326-6066.CIR-21-0480

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