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OTUD1 stabilizes PTEN to inhibit the PI3K/AKT and TNF-alpha/NF-kappaB signaling pathways and sensitize ccRCC to TKIs

Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma and has the highest mortality rate. For metastatic RCC, systemic drug therapy is the most important method in addition to surgical tumor reduction. In recent years, tyrosine kinase inhibitors (TKIs) targeting...

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Detalles Bibliográficos
Autores principales:	Liu, Wentao, Yan, Bin, Yu, Haixin, Ren, Jiannan, Peng, Mou, Zhu, Liang, Wang, Yinhuai, Jin, Xin, Yi, Lu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8898358/ https://www.ncbi.nlm.nih.gov/pubmed/35280681 http://dx.doi.org/10.7150/ijbs.68980

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