CRL4-DCAF8L1 Regulates BRCA1 and BARD1 Protein Stability

BRCA1 is frequently down-regulated in breast cancer, the underlying mechanism is unclear. Here we identified DCAF8L1, an X-linked gene product, as a DDB1-Cullin associated Factor (DCAF) for CUL4 E3 ligases to target BRCA1 and BARD1 for proteasomal degradation. Forced expression of DCAF8L1 caused red...

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Detalles Bibliográficos
Autores principales: Liu, Fei, Han, Qianying, Zhang, Ting, Chang, Fen, Deng, Jingcheng, Huang, Xiaotian, Wang, Weiping, Xu, Yongjie, Li, Qin, Xu, Luzheng, Zhang, Bo, Li, Wentong, Li, Li, Su, Yanrong, Li, Yang, Shao, Genze
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8898372/
https://www.ncbi.nlm.nih.gov/pubmed/35280675
http://dx.doi.org/10.7150/ijbs.57178

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