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Heterotopic ossification after total hip arthroplasty: When is development completed?

BACKGROUND: Heterotopic ossifications (HO) are a common complication after total hip arthroplasty (THA). Nonsteroidal anti-inflammatory drugs have proven to reduce the occurrence of HO. It is still unclear when the formation of HO is finished. Aim of our study was to answer this question. METHODS: I...

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Autores principales: Willburger, Roland E., Brinkhoff, Friederike, Nottenkämper, Jan, Krapp, Jan, Oberberg, Stella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8898402/
https://www.ncbi.nlm.nih.gov/pubmed/35248082
http://dx.doi.org/10.1186/s13018-022-02959-z
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author Willburger, Roland E.
Brinkhoff, Friederike
Nottenkämper, Jan
Krapp, Jan
Oberberg, Stella
author_facet Willburger, Roland E.
Brinkhoff, Friederike
Nottenkämper, Jan
Krapp, Jan
Oberberg, Stella
author_sort Willburger, Roland E.
collection PubMed
description BACKGROUND: Heterotopic ossifications (HO) are a common complication after total hip arthroplasty (THA). Nonsteroidal anti-inflammatory drugs have proven to reduce the occurrence of HO. It is still unclear when the formation of HO is finished. Aim of our study was to answer this question. METHODS: In a prospective study, the occurrence of periarticular HO was checked during the follow-up (FU) examinations. In total, 75 consecutive patients who underwent THA were included. To ensure a high follow-up rate, only patients with a life expectancy of at least 10 years were included. A medical ossification prophylaxis with mostly etoricoxib (90 mg once daily) was administered. Follow-up examinations were performed at 3 months, 1 year, 3, 5, and 10 years postoperatively. Each time, a clinical and radiological examination was carried out. The HO was graded according to Brooker’s method. RESULTS: Low-grade HO classified by Brooker grade I and II occurred significantly more frequent than HO grade III. In patients with present HO, a possible increase in Brooker stage could further be observed within 3 years postoperatively. After 3 years, the formation of HO was completed in all patients. CONCLUSION: Three years after THA, the formation of HO is complete. After more than 3 years postoperatively, if HO occurs or increases, other triggering causes such as new trauma, periarticular infection, or implant loosening should be considered.
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spelling pubmed-88984022022-03-16 Heterotopic ossification after total hip arthroplasty: When is development completed? Willburger, Roland E. Brinkhoff, Friederike Nottenkämper, Jan Krapp, Jan Oberberg, Stella J Orthop Surg Res Research Article BACKGROUND: Heterotopic ossifications (HO) are a common complication after total hip arthroplasty (THA). Nonsteroidal anti-inflammatory drugs have proven to reduce the occurrence of HO. It is still unclear when the formation of HO is finished. Aim of our study was to answer this question. METHODS: In a prospective study, the occurrence of periarticular HO was checked during the follow-up (FU) examinations. In total, 75 consecutive patients who underwent THA were included. To ensure a high follow-up rate, only patients with a life expectancy of at least 10 years were included. A medical ossification prophylaxis with mostly etoricoxib (90 mg once daily) was administered. Follow-up examinations were performed at 3 months, 1 year, 3, 5, and 10 years postoperatively. Each time, a clinical and radiological examination was carried out. The HO was graded according to Brooker’s method. RESULTS: Low-grade HO classified by Brooker grade I and II occurred significantly more frequent than HO grade III. In patients with present HO, a possible increase in Brooker stage could further be observed within 3 years postoperatively. After 3 years, the formation of HO was completed in all patients. CONCLUSION: Three years after THA, the formation of HO is complete. After more than 3 years postoperatively, if HO occurs or increases, other triggering causes such as new trauma, periarticular infection, or implant loosening should be considered. BioMed Central 2022-03-05 /pmc/articles/PMC8898402/ /pubmed/35248082 http://dx.doi.org/10.1186/s13018-022-02959-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Willburger, Roland E.
Brinkhoff, Friederike
Nottenkämper, Jan
Krapp, Jan
Oberberg, Stella
Heterotopic ossification after total hip arthroplasty: When is development completed?
title Heterotopic ossification after total hip arthroplasty: When is development completed?
title_full Heterotopic ossification after total hip arthroplasty: When is development completed?
title_fullStr Heterotopic ossification after total hip arthroplasty: When is development completed?
title_full_unstemmed Heterotopic ossification after total hip arthroplasty: When is development completed?
title_short Heterotopic ossification after total hip arthroplasty: When is development completed?
title_sort heterotopic ossification after total hip arthroplasty: when is development completed?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8898402/
https://www.ncbi.nlm.nih.gov/pubmed/35248082
http://dx.doi.org/10.1186/s13018-022-02959-z
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