Sustained glymphatic transport and impaired drainage to the nasal cavity observed in multiciliated cell ciliopathies with hydrocephalus

BACKGROUND: Hydrocephalus (increased ventricular size due to CSF accumulation) is a common finding in human ciliopathies and in mouse models with genetic depletion of the multiciliated cell (MCC) cilia machinery. However, the contribution of MCC to CSF dynamics and, the mechanism by which impaired M...

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Detalles Bibliográficos
Autores principales: Xue, Yuechuan, Gursky, Zachary, Monte, Brittany, Koundal, Sunil, Liu, Xiaodan, Lee, Hedok, Michurina, Tatyana V., Mellanson, Kennelia A., Zhao, Lucy, Nemajerova, Alice, Kahle, Kristopher T., Takemaru, Ken-Ichi, Enikolopov, Grigori, Peunova, Natalia I., Benveniste, Helene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8898469/
https://www.ncbi.nlm.nih.gov/pubmed/35248089
http://dx.doi.org/10.1186/s12987-022-00319-x

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