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Porous Cu-MOF nanostructures with anticancer properties prepared by a controllable ultrasound-assisted reverse micelle synthesis of Cu-MOF

The ultrasonic assisted reverse micelle method (UARM) was used to synthesize Cu-MOF from Cu(NO(3))(2)·3H(2)O and 2,6-pyridine dicarboxylic acid in a 1:1 molar proportion. It has been characterized using FT-IR, XRD, nitrogen adsorption analysis, SEM and TEM–EDX. The morphology of Cu-MOFs was spherica...

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Detalles Bibliográficos
Autores principales: Akhavan-Sigari, Reza, Zeraati, Malihe, Moghaddam-Manesh, Mohammadreza, Kazemzadeh, Parya, Hosseinzadegan, Sara, Chauhan, Narendra Pal Singh, Sargazi, Ghasem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8898484/
https://www.ncbi.nlm.nih.gov/pubmed/35248138
http://dx.doi.org/10.1186/s13065-022-00804-2
Descripción
Sumario:The ultrasonic assisted reverse micelle method (UARM) was used to synthesize Cu-MOF from Cu(NO(3))(2)·3H(2)O and 2,6-pyridine dicarboxylic acid in a 1:1 molar proportion. It has been characterized using FT-IR, XRD, nitrogen adsorption analysis, SEM and TEM–EDX. The morphology of Cu-MOFs was spherical, with an average particle size distribution of less than 100 nm. Using BET analysis, the surface area of Cu-MOF was found to be 284.94 m(2)/g. The porous morphology of Cu-MOF was also suggested by SEM and TEM analyses. It has anticancer properties against MCF-7 breast cancer cells. Cytotoxicity testing was performed on MCF-7 breast cancer cells using the MTT cell viability assay, and cell proliferation and viability were found to be approximately 24% higher than the control.