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Cognitive, EEG, and MRI features of COVID-19 survivors: a 10-month study
BACKGROUND AND OBJECTIVES: To explore cognitive, EEG, and MRI features in COVID-19 survivors up to 10 months after hospital discharge. METHODS: Adult patients with a recent diagnosis of COVID-19 and reporting subsequent cognitive complaints underwent neuropsychological assessment and 19-channel-EEG...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8898558/ https://www.ncbi.nlm.nih.gov/pubmed/35249144 http://dx.doi.org/10.1007/s00415-022-11047-5 |
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author | Cecchetti, Giordano Agosta, Federica Canu, Elisa Basaia, Silvia Barbieri, Alessandra Cardamone, Rosalinda Bernasconi, Maria Paola Castelnovo, Veronica Cividini, Camilla Cursi, Marco Vabanesi, Marco Impellizzeri, Matteo Lazzarin, Serena Marita Fanelli, Giovanna Franca Minicucci, Fabio Giacalone, Giacomo Falini, Andrea Falautano, Monica Rovere-Querini, Patrizia Roveri, Luisa Filippi, Massimo |
author_facet | Cecchetti, Giordano Agosta, Federica Canu, Elisa Basaia, Silvia Barbieri, Alessandra Cardamone, Rosalinda Bernasconi, Maria Paola Castelnovo, Veronica Cividini, Camilla Cursi, Marco Vabanesi, Marco Impellizzeri, Matteo Lazzarin, Serena Marita Fanelli, Giovanna Franca Minicucci, Fabio Giacalone, Giacomo Falini, Andrea Falautano, Monica Rovere-Querini, Patrizia Roveri, Luisa Filippi, Massimo |
author_sort | Cecchetti, Giordano |
collection | PubMed |
description | BACKGROUND AND OBJECTIVES: To explore cognitive, EEG, and MRI features in COVID-19 survivors up to 10 months after hospital discharge. METHODS: Adult patients with a recent diagnosis of COVID-19 and reporting subsequent cognitive complaints underwent neuropsychological assessment and 19-channel-EEG within 2 months (baseline, N = 49) and 10 months (follow-up, N = 33) after hospital discharge. A brain MRI was obtained for 36 patients at baseline. Matched healthy controls were included. Using eLORETA, EEG regional current densities and linear lagged connectivity values were estimated. Total brain and white matter hyperintensities (WMH) volumes were measured. Clinical and instrumental data were evaluated between patients and controls at baseline, and within patient whole group and with/without dysgeusia/hyposmia subgroups over time. Correlations among findings at each timepoint were computed. RESULTS: At baseline, 53% and 28% of patients showed cognitive and psychopathological disturbances, respectively, with executive dysfunctions correlating with acute-phase respiratory distress. Compared to healthy controls, patients also showed higher regional current density and connectivity at delta band, correlating with executive performances, and greater WMH load, correlating with verbal memory deficits. A reduction of cognitive impairment and delta band EEG connectivity were observed over time, while psychopathological symptoms persisted. Patients with acute dysgeusia/hyposmia showed lower improvement at memory tests than those without. Lower EEG delta band at baseline predicted worse cognitive functioning at follow-up. DISCUSSION: COVID-19 patients showed interrelated cognitive, EEG, and MRI abnormalities 2 months after hospital discharge. Cognitive and EEG findings improved at 10 months. Dysgeusia and hyposmia during acute COVID-19 were related with increased vulnerability in memory functions over time. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00415-022-11047-5. |
format | Online Article Text |
id | pubmed-8898558 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-88985582022-03-07 Cognitive, EEG, and MRI features of COVID-19 survivors: a 10-month study Cecchetti, Giordano Agosta, Federica Canu, Elisa Basaia, Silvia Barbieri, Alessandra Cardamone, Rosalinda Bernasconi, Maria Paola Castelnovo, Veronica Cividini, Camilla Cursi, Marco Vabanesi, Marco Impellizzeri, Matteo Lazzarin, Serena Marita Fanelli, Giovanna Franca Minicucci, Fabio Giacalone, Giacomo Falini, Andrea Falautano, Monica Rovere-Querini, Patrizia Roveri, Luisa Filippi, Massimo J Neurol Original Communication BACKGROUND AND OBJECTIVES: To explore cognitive, EEG, and MRI features in COVID-19 survivors up to 10 months after hospital discharge. METHODS: Adult patients with a recent diagnosis of COVID-19 and reporting subsequent cognitive complaints underwent neuropsychological assessment and 19-channel-EEG within 2 months (baseline, N = 49) and 10 months (follow-up, N = 33) after hospital discharge. A brain MRI was obtained for 36 patients at baseline. Matched healthy controls were included. Using eLORETA, EEG regional current densities and linear lagged connectivity values were estimated. Total brain and white matter hyperintensities (WMH) volumes were measured. Clinical and instrumental data were evaluated between patients and controls at baseline, and within patient whole group and with/without dysgeusia/hyposmia subgroups over time. Correlations among findings at each timepoint were computed. RESULTS: At baseline, 53% and 28% of patients showed cognitive and psychopathological disturbances, respectively, with executive dysfunctions correlating with acute-phase respiratory distress. Compared to healthy controls, patients also showed higher regional current density and connectivity at delta band, correlating with executive performances, and greater WMH load, correlating with verbal memory deficits. A reduction of cognitive impairment and delta band EEG connectivity were observed over time, while psychopathological symptoms persisted. Patients with acute dysgeusia/hyposmia showed lower improvement at memory tests than those without. Lower EEG delta band at baseline predicted worse cognitive functioning at follow-up. DISCUSSION: COVID-19 patients showed interrelated cognitive, EEG, and MRI abnormalities 2 months after hospital discharge. Cognitive and EEG findings improved at 10 months. Dysgeusia and hyposmia during acute COVID-19 were related with increased vulnerability in memory functions over time. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00415-022-11047-5. Springer Berlin Heidelberg 2022-03-06 2022 /pmc/articles/PMC8898558/ /pubmed/35249144 http://dx.doi.org/10.1007/s00415-022-11047-5 Text en © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Original Communication Cecchetti, Giordano Agosta, Federica Canu, Elisa Basaia, Silvia Barbieri, Alessandra Cardamone, Rosalinda Bernasconi, Maria Paola Castelnovo, Veronica Cividini, Camilla Cursi, Marco Vabanesi, Marco Impellizzeri, Matteo Lazzarin, Serena Marita Fanelli, Giovanna Franca Minicucci, Fabio Giacalone, Giacomo Falini, Andrea Falautano, Monica Rovere-Querini, Patrizia Roveri, Luisa Filippi, Massimo Cognitive, EEG, and MRI features of COVID-19 survivors: a 10-month study |
title | Cognitive, EEG, and MRI features of COVID-19 survivors: a 10-month study |
title_full | Cognitive, EEG, and MRI features of COVID-19 survivors: a 10-month study |
title_fullStr | Cognitive, EEG, and MRI features of COVID-19 survivors: a 10-month study |
title_full_unstemmed | Cognitive, EEG, and MRI features of COVID-19 survivors: a 10-month study |
title_short | Cognitive, EEG, and MRI features of COVID-19 survivors: a 10-month study |
title_sort | cognitive, eeg, and mri features of covid-19 survivors: a 10-month study |
topic | Original Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8898558/ https://www.ncbi.nlm.nih.gov/pubmed/35249144 http://dx.doi.org/10.1007/s00415-022-11047-5 |
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