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Hypovitaminosis D, oral potentially malignant disorders, and oral squamous cell carcinoma: a systematic review

BACKGROUND: Oral squamous cell carcinoma (OSCC) and potentially malignant oral disorders (OPMDs) could be associated with low levels of vitamin D. This systematic review aimed to determine the relationship between serum levels of vitamin D with OPMDs and OSCC. MATERIAL AND METHODS: This review was c...

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Autores principales: Maturana-Ramírez, Andrea, Aitken-Saavedra, Juan, de Guevara-Benítez, Arantxa Ladrón, Espinoza-Santander, Iris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medicina Oral S.L. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8898584/
https://www.ncbi.nlm.nih.gov/pubmed/35218642
http://dx.doi.org/10.4317/medoral.25049
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author Maturana-Ramírez, Andrea
Aitken-Saavedra, Juan
de Guevara-Benítez, Arantxa Ladrón
Espinoza-Santander, Iris
author_facet Maturana-Ramírez, Andrea
Aitken-Saavedra, Juan
de Guevara-Benítez, Arantxa Ladrón
Espinoza-Santander, Iris
author_sort Maturana-Ramírez, Andrea
collection PubMed
description BACKGROUND: Oral squamous cell carcinoma (OSCC) and potentially malignant oral disorders (OPMDs) could be associated with low levels of vitamin D. This systematic review aimed to determine the relationship between serum levels of vitamin D with OPMDs and OSCC. MATERIAL AND METHODS: This review was conducted according to Cochrane guidelines (PROSPERO CRD42020207382) on literature retrieved from the PubMed, Cochrane, and Web of Science databases. The antecedents extracted were study design, methodology, sample (country, number of patients, age, and sex), oral manifestations (type of lesion, location, prevalence, and follow-up), serum vitamin D levels or use of vitamin D supplements, results, and conclusions. RESULTS: Twelve articles were selected. Some of the most relevant findings were alterations in vitamin D could favor the progress of OPMDs to OSCC. Higher levels of vitamin D can increase levels of anti-inflammatory mediators, CD4+ T lymphocytes and CD8+ T lymphocytes and CD3+ T lymphocytes in intratumoral tissue. The normalization of vitamin D levels in patients with OSCC can increased cytotoxic activity of natural killer cells, favoring antitumor immune response. Vitamin D supplemented can lower adverse effects associated with chemotherapy like mucositis and pain. Tobacco can increase risk of developing OSCC altering vitamin D levels. CONCLUSIONS: Hypovitaminosis D could increase risk of developing OSCC from OPMDs, thus altering the immune response and it is associated with a lower survival rate in patients with OSCC, a greater recurrence of tumors in patients who underwent surgical treatment, and an increase in adverse reactions to chemotherapy. The use of vitamin D supplements can be a complement to primary therapy to prevent the recurrence of lesions and reduce adverse events associated with treatment. Key words:Oral squamous cell carcinoma (OSCC), Oral potentially malignant disorders (OPMDs), Vitamin D, Oral cancer.
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spelling pubmed-88985842022-03-17 Hypovitaminosis D, oral potentially malignant disorders, and oral squamous cell carcinoma: a systematic review Maturana-Ramírez, Andrea Aitken-Saavedra, Juan de Guevara-Benítez, Arantxa Ladrón Espinoza-Santander, Iris Med Oral Patol Oral Cir Bucal Review BACKGROUND: Oral squamous cell carcinoma (OSCC) and potentially malignant oral disorders (OPMDs) could be associated with low levels of vitamin D. This systematic review aimed to determine the relationship between serum levels of vitamin D with OPMDs and OSCC. MATERIAL AND METHODS: This review was conducted according to Cochrane guidelines (PROSPERO CRD42020207382) on literature retrieved from the PubMed, Cochrane, and Web of Science databases. The antecedents extracted were study design, methodology, sample (country, number of patients, age, and sex), oral manifestations (type of lesion, location, prevalence, and follow-up), serum vitamin D levels or use of vitamin D supplements, results, and conclusions. RESULTS: Twelve articles were selected. Some of the most relevant findings were alterations in vitamin D could favor the progress of OPMDs to OSCC. Higher levels of vitamin D can increase levels of anti-inflammatory mediators, CD4+ T lymphocytes and CD8+ T lymphocytes and CD3+ T lymphocytes in intratumoral tissue. The normalization of vitamin D levels in patients with OSCC can increased cytotoxic activity of natural killer cells, favoring antitumor immune response. Vitamin D supplemented can lower adverse effects associated with chemotherapy like mucositis and pain. Tobacco can increase risk of developing OSCC altering vitamin D levels. CONCLUSIONS: Hypovitaminosis D could increase risk of developing OSCC from OPMDs, thus altering the immune response and it is associated with a lower survival rate in patients with OSCC, a greater recurrence of tumors in patients who underwent surgical treatment, and an increase in adverse reactions to chemotherapy. The use of vitamin D supplements can be a complement to primary therapy to prevent the recurrence of lesions and reduce adverse events associated with treatment. Key words:Oral squamous cell carcinoma (OSCC), Oral potentially malignant disorders (OPMDs), Vitamin D, Oral cancer. Medicina Oral S.L. 2022-03 2022-02-20 /pmc/articles/PMC8898584/ /pubmed/35218642 http://dx.doi.org/10.4317/medoral.25049 Text en Copyright: © 2022 Medicina Oral S.L. https://creativecommons.org/licenses/by/2.5/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Maturana-Ramírez, Andrea
Aitken-Saavedra, Juan
de Guevara-Benítez, Arantxa Ladrón
Espinoza-Santander, Iris
Hypovitaminosis D, oral potentially malignant disorders, and oral squamous cell carcinoma: a systematic review
title Hypovitaminosis D, oral potentially malignant disorders, and oral squamous cell carcinoma: a systematic review
title_full Hypovitaminosis D, oral potentially malignant disorders, and oral squamous cell carcinoma: a systematic review
title_fullStr Hypovitaminosis D, oral potentially malignant disorders, and oral squamous cell carcinoma: a systematic review
title_full_unstemmed Hypovitaminosis D, oral potentially malignant disorders, and oral squamous cell carcinoma: a systematic review
title_short Hypovitaminosis D, oral potentially malignant disorders, and oral squamous cell carcinoma: a systematic review
title_sort hypovitaminosis d, oral potentially malignant disorders, and oral squamous cell carcinoma: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8898584/
https://www.ncbi.nlm.nih.gov/pubmed/35218642
http://dx.doi.org/10.4317/medoral.25049
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