Cargando…

Psychometric properties of the PROMIS Preference score (PROPr) in patients with rheumatological and psychosomatic conditions

BACKGROUND: The PROMIS Preference score (PROPr) is a new generic preference-based health-related quality of life (HRQoL) score that can be used as a health state utility (HSU) score for quality-adjusted life years (QALYs) in cost-utility analyses (CUAs). It is the first HSU score based on item respo...

Descripción completa

Detalles Bibliográficos
Autores principales: Klapproth, C. P., Fischer, F., Merbach, M., Rose, M., Obbarius, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8898596/
https://www.ncbi.nlm.nih.gov/pubmed/35249554
http://dx.doi.org/10.1186/s41927-022-00245-3
_version_ 1784663689532538880
author Klapproth, C. P.
Fischer, F.
Merbach, M.
Rose, M.
Obbarius, A.
author_facet Klapproth, C. P.
Fischer, F.
Merbach, M.
Rose, M.
Obbarius, A.
author_sort Klapproth, C. P.
collection PubMed
description BACKGROUND: The PROMIS Preference score (PROPr) is a new generic preference-based health-related quality of life (HRQoL) score that can be used as a health state utility (HSU) score for quality-adjusted life years (QALYs) in cost-utility analyses (CUAs). It is the first HSU score based on item response theory (IRT) and has demonstrated favorable psychometric properties in first analyses. The PROPr combines the seven PROMIS domains: cognition, depression, fatigue, pain, physical function, sleep disturbance, and ability to participate in social roles and activities. It was developed based on preferences of the US general population. The aim of this study was to validate the PROPr in a German inpatient sample and to compare it to the EQ-5D. METHODS: We collected PROPr and EQ-5D-5L data from 141 patients undergoing inpatient treatment in the rheumatology and psychosomatic departments. We evaluated the criterion and convergent validity, and ceiling and floor effects of the PROPr and compared those characteristics to those of the EQ-5D. RESULTS: The mean PROPr (0.26, 95% CI: 0.23; 0.29) and the mean EQ-5D (0.44, 95% CI: 0.38; 0.51) scores differed significantly (d = 0.18, p < 0.001). Compared to the EQ-5D, the PROPr scores were less scattered across the measurement range which has resulted in smaller confidence intervals of the mean scores. The Pearson correlation coefficient between the two scores was r = 0.72 (p < 0.001). Both scores showed fair agreement with an Intraclass Correlation Coefficient (ICC) of 0.48 (p < 0.05). The PROPr and EQ-5D demonstrated similar discrimination power across sex, age, and conditions. While the PROPr showed a floor effect, the EQ-5D showed a ceiling effect. CONCLUSION: The PROPr measures HSU considerably lower than the EQ-5D as a result of different construction, anchors and measurement ranges. Because QALYs derived with the EQ-5D are widely considered state-of-the-art, application of the PROPr for QALY measurements would be problematic. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s41927-022-00245-3.
format Online
Article
Text
id pubmed-8898596
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-88985962022-03-07 Psychometric properties of the PROMIS Preference score (PROPr) in patients with rheumatological and psychosomatic conditions Klapproth, C. P. Fischer, F. Merbach, M. Rose, M. Obbarius, A. BMC Rheumatol Research BACKGROUND: The PROMIS Preference score (PROPr) is a new generic preference-based health-related quality of life (HRQoL) score that can be used as a health state utility (HSU) score for quality-adjusted life years (QALYs) in cost-utility analyses (CUAs). It is the first HSU score based on item response theory (IRT) and has demonstrated favorable psychometric properties in first analyses. The PROPr combines the seven PROMIS domains: cognition, depression, fatigue, pain, physical function, sleep disturbance, and ability to participate in social roles and activities. It was developed based on preferences of the US general population. The aim of this study was to validate the PROPr in a German inpatient sample and to compare it to the EQ-5D. METHODS: We collected PROPr and EQ-5D-5L data from 141 patients undergoing inpatient treatment in the rheumatology and psychosomatic departments. We evaluated the criterion and convergent validity, and ceiling and floor effects of the PROPr and compared those characteristics to those of the EQ-5D. RESULTS: The mean PROPr (0.26, 95% CI: 0.23; 0.29) and the mean EQ-5D (0.44, 95% CI: 0.38; 0.51) scores differed significantly (d = 0.18, p < 0.001). Compared to the EQ-5D, the PROPr scores were less scattered across the measurement range which has resulted in smaller confidence intervals of the mean scores. The Pearson correlation coefficient between the two scores was r = 0.72 (p < 0.001). Both scores showed fair agreement with an Intraclass Correlation Coefficient (ICC) of 0.48 (p < 0.05). The PROPr and EQ-5D demonstrated similar discrimination power across sex, age, and conditions. While the PROPr showed a floor effect, the EQ-5D showed a ceiling effect. CONCLUSION: The PROPr measures HSU considerably lower than the EQ-5D as a result of different construction, anchors and measurement ranges. Because QALYs derived with the EQ-5D are widely considered state-of-the-art, application of the PROPr for QALY measurements would be problematic. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s41927-022-00245-3. BioMed Central 2022-03-07 /pmc/articles/PMC8898596/ /pubmed/35249554 http://dx.doi.org/10.1186/s41927-022-00245-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Klapproth, C. P.
Fischer, F.
Merbach, M.
Rose, M.
Obbarius, A.
Psychometric properties of the PROMIS Preference score (PROPr) in patients with rheumatological and psychosomatic conditions
title Psychometric properties of the PROMIS Preference score (PROPr) in patients with rheumatological and psychosomatic conditions
title_full Psychometric properties of the PROMIS Preference score (PROPr) in patients with rheumatological and psychosomatic conditions
title_fullStr Psychometric properties of the PROMIS Preference score (PROPr) in patients with rheumatological and psychosomatic conditions
title_full_unstemmed Psychometric properties of the PROMIS Preference score (PROPr) in patients with rheumatological and psychosomatic conditions
title_short Psychometric properties of the PROMIS Preference score (PROPr) in patients with rheumatological and psychosomatic conditions
title_sort psychometric properties of the promis preference score (propr) in patients with rheumatological and psychosomatic conditions
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8898596/
https://www.ncbi.nlm.nih.gov/pubmed/35249554
http://dx.doi.org/10.1186/s41927-022-00245-3
work_keys_str_mv AT klapprothcp psychometricpropertiesofthepromispreferencescoreproprinpatientswithrheumatologicalandpsychosomaticconditions
AT fischerf psychometricpropertiesofthepromispreferencescoreproprinpatientswithrheumatologicalandpsychosomaticconditions
AT merbachm psychometricpropertiesofthepromispreferencescoreproprinpatientswithrheumatologicalandpsychosomaticconditions
AT rosem psychometricpropertiesofthepromispreferencescoreproprinpatientswithrheumatologicalandpsychosomaticconditions
AT obbariusa psychometricpropertiesofthepromispreferencescoreproprinpatientswithrheumatologicalandpsychosomaticconditions