Use of sulforaphane in COVID-19: Clinical trials are needed

We read with interest the narrative review authored by Kiser et al. (2021), which discussed extensively the antioxidant effect and anti-inflammatory effect of sulforaphane, a dietary supplement found in high amounts in cruciferous vegetables that ais orally accessible and well-tolerated. Notably, in...

Descripción completa

Detalles Bibliográficos
Autores principales: Kow, Chia Siang, Ramachandram, Dinesh Sangarran, Hasan, Syed Shahzad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2022
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8898664/
https://www.ncbi.nlm.nih.gov/pubmed/35303531
http://dx.doi.org/10.1016/j.molimm.2022.03.001
_version_ 1784663708654370816
author Kow, Chia Siang
Ramachandram, Dinesh Sangarran
Hasan, Syed Shahzad
author_facet Kow, Chia Siang
Ramachandram, Dinesh Sangarran
Hasan, Syed Shahzad
author_sort Kow, Chia Siang
collection PubMed
description We read with interest the narrative review authored by Kiser et al. (2021), which discussed extensively the antioxidant effect and anti-inflammatory effect of sulforaphane, a dietary supplement found in high amounts in cruciferous vegetables that ais orally accessible and well-tolerated. Notably, in their review, the authors also discussed the potential use of sulforaphane in patients with coronavirus disease 2019 (COVID-19). Sulforaphane mediates the inhibitory effect on NLRP3 inflammasome activation and we believe that this could be the main mechanism where sulforaphane is useful for patients with COVID-19.
format Online
Article
Text
id pubmed-8898664
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Elsevier Ltd.
record_format MEDLINE/PubMed
spelling pubmed-88986642022-03-07 Use of sulforaphane in COVID-19: Clinical trials are needed Kow, Chia Siang Ramachandram, Dinesh Sangarran Hasan, Syed Shahzad Mol Immunol Letter to the Editor We read with interest the narrative review authored by Kiser et al. (2021), which discussed extensively the antioxidant effect and anti-inflammatory effect of sulforaphane, a dietary supplement found in high amounts in cruciferous vegetables that ais orally accessible and well-tolerated. Notably, in their review, the authors also discussed the potential use of sulforaphane in patients with coronavirus disease 2019 (COVID-19). Sulforaphane mediates the inhibitory effect on NLRP3 inflammasome activation and we believe that this could be the main mechanism where sulforaphane is useful for patients with COVID-19. Elsevier Ltd. 2022-05 2022-03-07 /pmc/articles/PMC8898664/ /pubmed/35303531 http://dx.doi.org/10.1016/j.molimm.2022.03.001 Text en © 2022 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Letter to the Editor
Kow, Chia Siang
Ramachandram, Dinesh Sangarran
Hasan, Syed Shahzad
Use of sulforaphane in COVID-19: Clinical trials are needed
title Use of sulforaphane in COVID-19: Clinical trials are needed
title_full Use of sulforaphane in COVID-19: Clinical trials are needed
title_fullStr Use of sulforaphane in COVID-19: Clinical trials are needed
title_full_unstemmed Use of sulforaphane in COVID-19: Clinical trials are needed
title_short Use of sulforaphane in COVID-19: Clinical trials are needed
title_sort use of sulforaphane in covid-19: clinical trials are needed
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8898664/
https://www.ncbi.nlm.nih.gov/pubmed/35303531
http://dx.doi.org/10.1016/j.molimm.2022.03.001
work_keys_str_mv AT kowchiasiang useofsulforaphaneincovid19clinicaltrialsareneeded
AT ramachandramdineshsangarran useofsulforaphaneincovid19clinicaltrialsareneeded
AT hasansyedshahzad useofsulforaphaneincovid19clinicaltrialsareneeded

Ejemplares similares