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Cross-species tropism and antigenic landscapes of circulating SARS-CoV-2 variants

Mutations in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike receptor-binding domain (RBD) may alter viral host tropism and affect the activities of neutralizing antibodies. Here, we investigated 153 RBD mutants and 11 globally circulating variants of concern (VOCs) and varian...

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Autores principales: Zhang, Yali, Wei, Min, Wu, Yangtao, Wang, Juan, Hong, Yuting, Huang, Yang, Yuan, Lunzhi, Ma, Jian, Wang, Kai, Wang, Shaojuan, Shi, Yang, Wang, Zikang, Guo, Huilin, Xiao, Jin, Yang, Chuanlai, Ye, Jianghui, Chen, Jijing, Liu, Yuxi, Fu, Baorong, Lan, Miaolin, Gong, Peixuan, Huang, Zehong, Su, Yingying, Chen, Yixin, Zhang, Tianying, Zhang, Jun, Zhu, Huachen, Yu, Hai, Yuan, Quan, Cheng, Tong, Guan, Yi, Xia, Ningshao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8898742/
https://www.ncbi.nlm.nih.gov/pubmed/35303476
http://dx.doi.org/10.1016/j.celrep.2022.110558
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author Zhang, Yali
Wei, Min
Wu, Yangtao
Wang, Juan
Hong, Yuting
Huang, Yang
Yuan, Lunzhi
Ma, Jian
Wang, Kai
Wang, Shaojuan
Shi, Yang
Wang, Zikang
Guo, Huilin
Xiao, Jin
Yang, Chuanlai
Ye, Jianghui
Chen, Jijing
Liu, Yuxi
Fu, Baorong
Lan, Miaolin
Gong, Peixuan
Huang, Zehong
Su, Yingying
Chen, Yixin
Zhang, Tianying
Zhang, Jun
Zhu, Huachen
Yu, Hai
Yuan, Quan
Cheng, Tong
Guan, Yi
Xia, Ningshao
author_facet Zhang, Yali
Wei, Min
Wu, Yangtao
Wang, Juan
Hong, Yuting
Huang, Yang
Yuan, Lunzhi
Ma, Jian
Wang, Kai
Wang, Shaojuan
Shi, Yang
Wang, Zikang
Guo, Huilin
Xiao, Jin
Yang, Chuanlai
Ye, Jianghui
Chen, Jijing
Liu, Yuxi
Fu, Baorong
Lan, Miaolin
Gong, Peixuan
Huang, Zehong
Su, Yingying
Chen, Yixin
Zhang, Tianying
Zhang, Jun
Zhu, Huachen
Yu, Hai
Yuan, Quan
Cheng, Tong
Guan, Yi
Xia, Ningshao
author_sort Zhang, Yali
collection PubMed
description Mutations in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike receptor-binding domain (RBD) may alter viral host tropism and affect the activities of neutralizing antibodies. Here, we investigated 153 RBD mutants and 11 globally circulating variants of concern (VOCs) and variants of interest (VOIs) (including Omicron) for their antigenic changes and cross-species tropism in cells expressing 18 ACE2 orthologs. Several RBD mutations strengthened viral infectivity in cells expressing ACE2 orthologs of non-human animals, particularly those less susceptible to the ancestral strain. The mutations surrounding amino acids (aas) 439–448 and aa 484 are more likely to cause neutralization resistance. Strikingly, enhanced cross-species infection potential in the mouse and ferret, instead of the neutralization-escape scores of the mutations, account for the positive correlation with the cumulative prevalence of mutations in humans. These findings present insights for potential drivers of circulating SARS-CoV-2 variants and provide informative parameters for tracking and forecasting spreading mutations.
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spelling pubmed-88987422022-03-07 Cross-species tropism and antigenic landscapes of circulating SARS-CoV-2 variants Zhang, Yali Wei, Min Wu, Yangtao Wang, Juan Hong, Yuting Huang, Yang Yuan, Lunzhi Ma, Jian Wang, Kai Wang, Shaojuan Shi, Yang Wang, Zikang Guo, Huilin Xiao, Jin Yang, Chuanlai Ye, Jianghui Chen, Jijing Liu, Yuxi Fu, Baorong Lan, Miaolin Gong, Peixuan Huang, Zehong Su, Yingying Chen, Yixin Zhang, Tianying Zhang, Jun Zhu, Huachen Yu, Hai Yuan, Quan Cheng, Tong Guan, Yi Xia, Ningshao Cell Rep Article Mutations in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike receptor-binding domain (RBD) may alter viral host tropism and affect the activities of neutralizing antibodies. Here, we investigated 153 RBD mutants and 11 globally circulating variants of concern (VOCs) and variants of interest (VOIs) (including Omicron) for their antigenic changes and cross-species tropism in cells expressing 18 ACE2 orthologs. Several RBD mutations strengthened viral infectivity in cells expressing ACE2 orthologs of non-human animals, particularly those less susceptible to the ancestral strain. The mutations surrounding amino acids (aas) 439–448 and aa 484 are more likely to cause neutralization resistance. Strikingly, enhanced cross-species infection potential in the mouse and ferret, instead of the neutralization-escape scores of the mutations, account for the positive correlation with the cumulative prevalence of mutations in humans. These findings present insights for potential drivers of circulating SARS-CoV-2 variants and provide informative parameters for tracking and forecasting spreading mutations. The Authors. 2022-03-22 2022-03-07 /pmc/articles/PMC8898742/ /pubmed/35303476 http://dx.doi.org/10.1016/j.celrep.2022.110558 Text en © 2022 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Zhang, Yali
Wei, Min
Wu, Yangtao
Wang, Juan
Hong, Yuting
Huang, Yang
Yuan, Lunzhi
Ma, Jian
Wang, Kai
Wang, Shaojuan
Shi, Yang
Wang, Zikang
Guo, Huilin
Xiao, Jin
Yang, Chuanlai
Ye, Jianghui
Chen, Jijing
Liu, Yuxi
Fu, Baorong
Lan, Miaolin
Gong, Peixuan
Huang, Zehong
Su, Yingying
Chen, Yixin
Zhang, Tianying
Zhang, Jun
Zhu, Huachen
Yu, Hai
Yuan, Quan
Cheng, Tong
Guan, Yi
Xia, Ningshao
Cross-species tropism and antigenic landscapes of circulating SARS-CoV-2 variants
title Cross-species tropism and antigenic landscapes of circulating SARS-CoV-2 variants
title_full Cross-species tropism and antigenic landscapes of circulating SARS-CoV-2 variants
title_fullStr Cross-species tropism and antigenic landscapes of circulating SARS-CoV-2 variants
title_full_unstemmed Cross-species tropism and antigenic landscapes of circulating SARS-CoV-2 variants
title_short Cross-species tropism and antigenic landscapes of circulating SARS-CoV-2 variants
title_sort cross-species tropism and antigenic landscapes of circulating sars-cov-2 variants
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8898742/
https://www.ncbi.nlm.nih.gov/pubmed/35303476
http://dx.doi.org/10.1016/j.celrep.2022.110558
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