Cargando…

Exogenous Parathyroid Hormone Alleviates Intervertebral Disc Degeneration through the Sonic Hedgehog Signalling Pathway Mediated by CREB

As an important hormone that regulates the balance of calcium and phosphorus, parathyroid hormone (PTH) has also been found to have an important function in intervertebral disc degeneration (IVDD). Our aim was to investigate the mechanism by which PTH alleviates IVDD. In this study, the PTH 1 recept...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, You, Wei, Yifan, Li, He, Che, Hui, Miao, Dengshun, Ma, Cheng, Ren, Yongxin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8898813/ https://www.ncbi.nlm.nih.gov/pubmed/35265269 http://dx.doi.org/10.1155/2022/9955677

Ejemplares similares

Hedgehog proteins and parathyroid hormone‐related protein are involved in intervertebral disc maturation, degeneration, and calcification
por: Bach, Frances C., et al.
Publicado: (2019)

Bmi deficiency causes oxidative stress and intervertebral disc degeneration which can be alleviated by antioxidant treatment
por: Zhang, Qunhu, et al.
Publicado: (2020)

Oestrogen and parathyroid hormone alleviate lumbar intervertebral disc degeneration in ovariectomized rats and enhance Wnt/β-catenin pathway activity
por: Jia, Haobo, et al.
Publicado: (2016)

Formation of the sacrum requires down-regulation of sonic hedgehog signaling in the sacral intervertebral discs
por: Bonavita, Raffaella, et al.
Publicado: (2018)

Exogenous Indian hedgehog antagonist damages intervertebral discs homeostasis in adult mice
por: Chen, Ran, et al.
Publicado: (2022)

p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle
por: Che, Hui, et al.
Publicado: (2020)

Synergistic effects of high dietary calcium and exogenous parathyroid hormone in promoting osteoblastic bone formation in mice
por: Feng, Yuxu, et al.
Publicado: (2015)

Senolytics: Eliminating Senescent Cells and Alleviating Intervertebral Disc Degeneration
por: Wu, Yuhao, et al.
Publicado: (2022)

Degeneration of the intervertebral disc
por: Urban, Jill PG, et al.
Publicado: (2003)

Exogenous PTH 1-34 Attenuates Impaired Fracture Healing in Endogenous PTH Deficiency Mice via Activating Indian Hedgehog Signaling Pathway and Accelerating Endochondral Ossification
por: Ma, Cheng, et al.
Publicado: (2022)

Sirt1 protects against intervertebral disc degeneration induced by 1,25-dihydroxyvitamin D insufficiency in mice by inhibiting the NF-κB inflammatory pathway
por: Wang, Peng, et al.
Publicado: (2023)

Sonic Hedgehog: a lipid speciated hormone?
por: Long, Jun, et al.
Publicado: (2015)

Research on the function and related mechanism of P27 gene in the intervertebral disc degeneration of mice
por: Liu, Xiao, et al.
Publicado: (2017)

Pathomechanism of intervertebral disc degeneration
por: Oichi, Takeshi, et al.
Publicado: (2020)

Treatment of Intervertebral Disc Degeneration
por: Xin, Jingguo, et al.
Publicado: (2022)

Macrophages and Intervertebral Disc Degeneration
por: Koroth, Jinsha, et al.
Publicado: (2023)

The Immune Privilege of the Intervertebral Disc: Implications for Intervertebral Disc Degeneration Treatment
por: Sun, Zhen, et al.
Publicado: (2020)

The Proteolysis of ECM in Intervertebral Disc Degeneration
por: Liang, Huaizhen, et al.
Publicado: (2022)

How to enhance the ability of mesenchymal stem cells to alleviate intervertebral disc degeneration
por: Zhang, Qing-Xiang, et al.
Publicado: (2023)

Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration
por: Le Maitre, Christine Lyn, et al.
Publicado: (2007)

Can Manganese Dioxide Microspheres be Used as Intermediaries to Alleviate Intervertebral Disc Degeneration With Strengthening Drugs?
por: Zhang, Wentao, et al.
Publicado: (2022)

Intervertebral Disc Biology: Genetic Basis of Disc Degeneration
por: Munir, Sabrina, et al.
Publicado: (2018)

Angiogenesis in the degeneration of the lumbar intervertebral disc
por: David, Gh, et al.
Publicado: (2010)

Intervertebral disc degeneration therapies in human
por: Richardson, Stephen M
Publicado: (2015)

Genetic factors in intervertebral disc degeneration
por: Feng, Yi, et al.
Publicado: (2016)

The Role of Adipokines in Intervertebral Disc Degeneration
por: Sharma, Anirudh
Publicado: (2018)

Molecular Mechanisms of Intervertebral Disc Degeneration
por: Rider, Sean M., et al.
Publicado: (2018)

Genetic Therapy for Intervertebral Disc Degeneration
por: Roh, Eun Ji, et al.
Publicado: (2021)

Cervical intervertebral disc degeneration and dizziness
por: Liu, Tang-Hua, et al.
Publicado: (2021)

The role of ferroptosis in intervertebral disc degeneration
por: Fan, Chunyang, et al.
Publicado: (2023)

Role of Necroptosis in Intervertebral Disc Degeneration
por: Khaleque, Md Abdul, et al.
Publicado: (2023)

Mitochondrial quality control in intervertebral disc degeneration
por: Song, Yu, et al.
Publicado: (2021)

Quercetin Alleviates Intervertebral Disc Degeneration by Modulating p38 MAPK-Mediated Autophagy
por: Zhang, Shuwen, et al.
Publicado: (2021)

Platelet-derived extracellular vesicles ameliorate intervertebral disc degeneration by alleviating mitochondrial dysfunction
por: Dai, Zhanqiu, et al.
Publicado: (2022)

Sonic Hedgehog in SCLC
por: Laukkanen, Mikko O., et al.
Publicado: (2015)

Epoxyeicosanoids prevent intervertebral disc degeneration in vitro and in vivo
por: Li, Jing, et al.
Publicado: (2016)

Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: implications for the pathogenesis of intervertebral disc degeneration
por: Millward-Sadler, S Jane, et al.
Publicado: (2009)

Editorial: Cell-based therapeutics for intervertebral disc degeneration
por: Li, Zhen, et al.
Publicado: (2023)

The circadian rhythm in intervertebral disc degeneration: an autophagy connection
por: Zhang, Tai-Wei, et al.
Publicado: (2020)

Concerns about cell therapy for intervertebral disc degeneration
por: Peng, Baogan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_uccrnc487ts088blvvumvgrpri