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Depletion and Dysfunction of Dendritic Cells: Understanding SARS-CoV-2 Infection

Uncontrolled severe acute respiratory syndrome-coronavirus (SARS-CoV)-2 infection is closely related to disorders of the innate immune and delayed adaptive immune systems. Dendritic cells (DCs) “bridge” innate immunity and adaptive immunity. DCs have important roles in defending against SARS-CoV-2 i...

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Autores principales: Chang, Teding, Yang, Jingzhi, Deng, Hai, Chen, Deng, Yang, XiangPing, Tang, Zhao-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8898834/
https://www.ncbi.nlm.nih.gov/pubmed/35265087
http://dx.doi.org/10.3389/fimmu.2022.843342
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author Chang, Teding
Yang, Jingzhi
Deng, Hai
Chen, Deng
Yang, XiangPing
Tang, Zhao-Hui
author_facet Chang, Teding
Yang, Jingzhi
Deng, Hai
Chen, Deng
Yang, XiangPing
Tang, Zhao-Hui
author_sort Chang, Teding
collection PubMed
description Uncontrolled severe acute respiratory syndrome-coronavirus (SARS-CoV)-2 infection is closely related to disorders of the innate immune and delayed adaptive immune systems. Dendritic cells (DCs) “bridge” innate immunity and adaptive immunity. DCs have important roles in defending against SARS-CoV-2 infection. In this review, we summarize the latest research concerning the role of DCs in SARS-CoV-2 infection. We focus on the complex interplay between DCs and SARS-CoV-2: pyroptosis-induced activation; activation of the renin–angiotensin–aldosterone system; and activation of dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin. We also discuss the decline in DC number, the impaired antigen-presentation capability, and the reduced production of type-I interferon of DCs in severe SARS-CoV-2 infection. In addition, we discuss the potential mechanisms for pathological activation of DCs to understand the pattern of SARS-CoV-2 infection. Lastly, we provide a brief overview of novel vaccination and immunotherapy strategies based on DC targeting to overcome SARS-CoV-2 infection.
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spelling pubmed-88988342022-03-08 Depletion and Dysfunction of Dendritic Cells: Understanding SARS-CoV-2 Infection Chang, Teding Yang, Jingzhi Deng, Hai Chen, Deng Yang, XiangPing Tang, Zhao-Hui Front Immunol Immunology Uncontrolled severe acute respiratory syndrome-coronavirus (SARS-CoV)-2 infection is closely related to disorders of the innate immune and delayed adaptive immune systems. Dendritic cells (DCs) “bridge” innate immunity and adaptive immunity. DCs have important roles in defending against SARS-CoV-2 infection. In this review, we summarize the latest research concerning the role of DCs in SARS-CoV-2 infection. We focus on the complex interplay between DCs and SARS-CoV-2: pyroptosis-induced activation; activation of the renin–angiotensin–aldosterone system; and activation of dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin. We also discuss the decline in DC number, the impaired antigen-presentation capability, and the reduced production of type-I interferon of DCs in severe SARS-CoV-2 infection. In addition, we discuss the potential mechanisms for pathological activation of DCs to understand the pattern of SARS-CoV-2 infection. Lastly, we provide a brief overview of novel vaccination and immunotherapy strategies based on DC targeting to overcome SARS-CoV-2 infection. Frontiers Media S.A. 2022-02-21 /pmc/articles/PMC8898834/ /pubmed/35265087 http://dx.doi.org/10.3389/fimmu.2022.843342 Text en Copyright © 2022 Chang, Yang, Deng, Chen, Yang and Tang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Chang, Teding
Yang, Jingzhi
Deng, Hai
Chen, Deng
Yang, XiangPing
Tang, Zhao-Hui
Depletion and Dysfunction of Dendritic Cells: Understanding SARS-CoV-2 Infection
title Depletion and Dysfunction of Dendritic Cells: Understanding SARS-CoV-2 Infection
title_full Depletion and Dysfunction of Dendritic Cells: Understanding SARS-CoV-2 Infection
title_fullStr Depletion and Dysfunction of Dendritic Cells: Understanding SARS-CoV-2 Infection
title_full_unstemmed Depletion and Dysfunction of Dendritic Cells: Understanding SARS-CoV-2 Infection
title_short Depletion and Dysfunction of Dendritic Cells: Understanding SARS-CoV-2 Infection
title_sort depletion and dysfunction of dendritic cells: understanding sars-cov-2 infection
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8898834/
https://www.ncbi.nlm.nih.gov/pubmed/35265087
http://dx.doi.org/10.3389/fimmu.2022.843342
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